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UniProtKB/Swiss-Prot entry P28469

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1A_MACMU
Primary accession number P28469
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1A
Synonyms EC 1.1.1.1
Alcohol dehydrogenase subunit alpha
Gene name
Name: ADH1A
Synonyms: ADH1
From
Macaca mulatta (Rhesus macaque) [TaxID: 9544] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=1618764 [NCBI, ExPASy, EBI, Israel, Japan]
Light D.R., Dennis M.S., Forsythe I.J., Liu C.C., Green D.W., Kratzer D., Plapp B.V.;
"Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity.";
J. Biol. Chem. 267:12592-12599(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M81807; AAA36830.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I55359; I55359.
RefSeq NP_001036230.1; -.
UniGene Mmu.3289
3D structure databases
HSSP P00325; 1HDZ. [HSSP ENTRY / PDB]
SMR P28469; 2-375.
ModBase P28469.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet P28469.
Genome annotation databases
Ensembl ENSMMUG00000018738; Macaca mulatta. [Contig view]
GeneID 707682; -.
KEGG mcc:707682; -.
Phylogenomic databases
HOVERGEN P28469; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   375  374     Alcohol dehydrogenase 1A. PRO_0000160659
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   175   175        Zinc 1; catalytic (By similarity). 
MOD_RES   2     2        N-acetylserine (By similarity). 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 39913 Da [This is the MW of the unprocessed precursor] CRC64: 8B0DDC03673AA8DA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEVMK PFSIEDVEVA PPKAYEVRIK MVTVGICGTD DHVVSGTMVT 

        70         80         90        100        110        120 
PLPVILGHEA AGIVESVGEG VTTVEPGDKV IPLALPQCGK CRICKTPERN YCLKNDVSNP 

       130        140        150        160        170        180 
RGTLQDGTSR FTCRGKPIHH FLGVSTFSQY TVVDENAVAK IDAASPMEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 

       310        320        330        340        350        360 
NLSINPMLLL TGRTWKGAVY GGFKSKEDIP KLVADFMAKK FSLDALITHV LPFEKINEGF 

       370 
DLLRSGKSIR TILTF
P28469 in FASTA format

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