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UniProtKB/Swiss-Prot entry P28776

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name I23O_MOUSE
Primary accession number P28776
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on December 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name Indoleamine 2,3-dioxygenase
Synonyms IDO
EC 1.13.11.52
Indoleamine-pyrrole 2,3-dioxygenase
Gene name
Name: Indo
Synonyms: Ido
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1016/0378-1119(91)90154-4; PubMed=1937018 [NCBI, ExPASy, EBI, Israel, Japan]
Habara-Ohkubo A., Takikawa O., Yoshida R.;
"Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase.";
Gene 105:221-227(1991).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=NMRI;
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M69109; AAA37872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC049931; AAH49931.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JH0492; JH0492.
RefSeq NP_032350.1; -.
UniGene Mm.392
3D structure databases
ModBase P28776.
Organism-specific databases
MGI MGI:96416; Indo.
Gene expression databases
ArrayExpress P28776; -.
CleanEx MM_INDO; -.
GermOnline ENSMUSG00000031551; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from MGI).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0033754; Molecular function: indoleamine 2,3-dioxygenase activity (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004833; Molecular function: tryptophan 2,3-dioxygenase activity (inferred from direct assay from MGI).
GO:0006952; Biological process: defense response (traceable author statement from MGI).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019441; Biological process: tryptophan catabolic process to kynurenine (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000898; Indolamine_dOase.
Graphical view of domain structure.
Pfam PF01231; IDO; 1.
Pfam graphical view of domain structure.
PROSITE PS00876; IDO_1; 1.
PS00877; IDO_2; 1.
ProtoNet P28776.
Genome annotation databases
Ensembl ENSMUSG00000031551; Mus musculus. [Contig view]
GeneID 15930; -.
KEGG mmu:15930; -.
Phylogenomic databases
HOGENOM P28776; -.
HOVERGEN P28776; -.
Other
NextBio 288648; -.
SOURCE Indo; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Direct protein sequencing; Heme; Iron; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   407  407     Indoleamine 2,3-dioxygenase. PRO_0000215205
METAL   350   350        Iron (heme proximal ligand) (By similarity). 
Sequence information
Length: 407 AA [This is the length of the unprocessed precursor] Molecular weight: 45641 Da [This is the MW of the unprocessed precursor] CRC64: 317681EABF96A727 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALSKISPTE GSRRILEDHH IDEDVGFALP HPLVELPDAY SPWVLVARNL PVLIENGQLR 

        70         80         90        100        110        120 
EEVEKLPTLS TDGLRGHRLQ RLAHLALGYI TMAYVWNRGD DDVRKVLPRN IAVPYCELSE 

       130        140        150        160        170        180 
KLGLPPILSY ADCVLANWKK KDPNGPMTYE NMDILFSFPG GDCDKGFFLV SLLVEIAASP 

       190        200        210        220        230        240 
AIKAIPTVSS AVERQDLKAL EKALHDIATS LEKAKEIFKR MRDFVDPDTF FHVLRIYLSG 

       250        260        270        280        290        300 
WKCSSKLPEG LLYEGVWDTP KMFSGGSAGQ SSIFQSLDVL LGIKHEAGKE SPAEFLQEMR 

       310        320        330        340        350        360 
EYMPPAHRNF LFFLESAPPV REFVISRHNE DLTKAYNECV NGLVSVRKFH LAIVDTYIMK 

       370        380        390        400 
PSKKKPTDGD KSEEPSNVES RGTGGTNPMT FLRSVKDTTE KALLSWP
P28776 in FASTA format

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