ID   LUXC2_PHOLE             Reviewed;         478 AA.
AC   P29236;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-NOV-2008, entry version 38.
DE   RecName: Full=Acyl-CoA reductase;
DE            EC=1.2.1.50;
GN   Name=luxC;
OS   Photobacterium leiognathi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Photobacterium.
OX   NCBI_TaxID=658;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25521 / L1 / CIP 665;
RX   MEDLINE=92007870; PubMed=1915359;
RA   Lee C.Y., Szittner R.B., Meighen E.A.;
RT   "The lux genes of the luminous bacterial symbiont, Photobacterium
RT   leiognathi, of the ponyfish. Nucleotide sequence, difference in gene
RT   organization, and high expression in mutant Escherichia coli.";
RL   Eur. J. Biochem. 201:161-167(1991).
CC   -!- FUNCTION: LuxC is the fatty acid reductase enzyme responsible for
CC       synthesis of the aldehyde substrate for the luminescent reaction
CC       catalyzed by luciferase.
CC   -!- CATALYTIC ACTIVITY: A long-chain aldehyde + CoA + NADP(+) = a
CC       long-chain acyl-CoA + NADPH.
CC   -!- PATHWAY: Lipid metabolism; bioluminescent fatty acid reduction.
CC   -!- SIMILARITY: Belongs to the luxC family.
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DR   EMBL; M63594; AAA25616.1; -; Genomic_DNA.
DR   PIR; S17836; S17836.
DR   GO; GO:0019109; F:acyl-CoA reductase activity; IEA:InterPro.
DR   GO; GO:0050062; F:long-chain-fatty-acyl-CoA reductase activity; IEA:EC.
DR   GO; GO:0008218; P:bioluminescence; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR008670; LuxC.
DR   Pfam; PF05893; LuxC; 1.
PE   3: Inferred from homology;
KW   Luminescence; NADP; Oxidoreductase.
FT   CHAIN         1    478       Acyl-CoA reductase.
FT                                /FTId=PRO_0000220197.
SQ   SEQUENCE   478 AA;  53713 MW;  4716EF699BF7FE4A CRC64;
     MIKKIPMIIG GVVQNTSGYG MRELTLNNNK VNIPIITQSD VEAIQSLNIE NKLTINQIVN
     FLYTVGQKWK SETYSRRLTY IRDLIKFLGY SQEMAKLEAN WISMILCSKS ALYDIVENDL
     SSRHIIDEWI PQGECYVKAL PKGKSVHLLA GNVPLSGVTS ILRAILTKNE CIIKTSSADP
     FTATALVNSF IDVDAEHPIT RSISVMYWSH SEDLAIPKQI MSCADVVIAW GGDDAIKWAT
     EHAPSHADIL KFGPKKSISI VDNPTDIKAA AIGVAHDICF YDQQACFSTQ DIYYIGDSID
     IFFDELAQQL NKYKDILPKG ERNFDEKAAF SLTERECLFA KYKVQKGESQ SWLLTQSPAG
     SFGNQPLSRS AYIHQVNDIS EVIPFVHKAV TQTVAIAPWE SSFKYRDILA EHGAERIIEA
     GMNNIFRVGG AHDGMRPLQR LVNYISHERP STYTTKDVSV KIEQTRYLEE DKFLVFVP
//