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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-37.
STRAIN=ATCC 13543 / NRRL B-3784;
DOI=10.1021/bi00240a012; PubMed=1905152 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"The NADH-binding subunit of the energy-transducing NADH-ubiquinone oxidoreductase of Paracoccus denitrificans: gene cloning and deduced primary structure.";
Biochemistry 30:6422-6428(1991).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8, AND PROTEIN SEQUENCE OF 1-37 AND 194-203.
STRAIN=ATCC 13543 / NRRL B-3784;
DOI=10.1021/bi00099a027; PubMed=1909571 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"Characterization of the 25-kilodalton subunit of the energy-transducing NADH-ubiquinone oxidoreductase of Paracoccus denitrificans: sequence similarity to the 24-kilodalton subunit of the flavoprotein fraction of mammalian complex I.";
Biochemistry 30:8678-8684(1991).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 416-431.
DOI=10.1016/0003-9861(92)90542-5; PubMed=1605643 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"Structural features of the 66-kDa subunit of the energy-transducing NADH-ubiquinone oxidoreductase (NDH-1) of Paracoccus denitrificans.";
Arch. Biochem. Biophys. 296:40-48(1992).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- COFACTOR: Binds 1 FMN (Potential).
- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
- SUBUNIT: NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
- SIMILARITY: Belongs to the complex I 51 kDa subunit family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 431 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47191 Da [This is the MW of the unprocessed precursor] |
CRC64: AA25C5A0A7570048 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLNDQDRIFT NLYGMGDRSL AGAKKRGHWD GTAAIIQRGR DKIIDEMKAS GLRGRGGAGF
70 80 90 100 110 120
PTGMKWSFMP KESDGRPSYL VINADESEPA TCKDREIMRH DPHTLIEGAL IASFAMGAHA
130 140 150 160 170 180
AYIYIRGEFI REREALQAAI DECYDAGLLG RNAAGSGWDF DLYLHHGAGA YICGEETALL
190 200 210 220 230 240
ESLEGKKGMP RMKPPFPAGA GLYGCPTTVN NVESIAVVPT ILRRGAEWFA SFGRPNNAGV
250 260 270 280 290 300
KLFGLTGHVN TPCVVEEAMS IPMRELIEKH GGGIRGGWKN LKAVIPGGAS CPVLTAEQCE
310 320 330 340 350 360
NAIMDYDGMR DVRSSFGTAC MIVMDQSTDV VKAIWRLSKF FKHESCGQCT PCREGTGWMM
370 380 390 400 410 420
RVMERLVRGD AEVEEIDMLF DVTKQVEGHT ICALGDAAAW PIQGLIRNFR EEIEDRIKAK
430
RTGRMGAMAA E
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P29913 in FASTA format |
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