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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal gland;
DOI=10.1016/0006-291X(90)91460-A; PubMed=2350348 [NCBI, ExPASy, EBI, Israel, Japan]
Matsukawa N.,
Nonaka Y.,
Ying Z.,
Higaki J.,
Ogihara T.,
Okamoto M.;
"Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta).";
Biochem. Biophys. Res. Commun. 169:245-252(1990).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0960-0760(92)90367-R; PubMed=1562515 [NCBI, ExPASy, EBI, Israel, Japan]
Okamoto M.,
Nonaka Y.;
"Molecular biology of rat steroid 11 beta-hydroxylase [P450(11 beta)] and aldosterone synthase [P450(11 beta, aldo)].";
J. Steroid Biochem. Mol. Biol. 41:415-419(1992).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Adrenal gland;
DOI=10.1006/bbrc.1993.1792; PubMed=8333830 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou M.,
Gomez-Sanchez C.E.;
"Cloning and expression of a rat cytochrome P-450 11 beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.";
Biochem. Biophys. Res. Commun. 194:112-117(1993).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND VARIANT GLY-84.
PubMed=8468320 [NCBI, ExPASy, EBI, Israel, Japan]
Nomura M.,
Morohashi K.,
Kirita S.,
Nonaka Y.,
Okamoto M.,
Nawata H.,
Omura T.;
"Three forms of rat CYP11B genes: 11 beta-hydroxylase gene, aldosterone synthase gene, and a novel gene.";
J. Biochem. 113:144-152(1993).
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[5]
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PROTEIN SEQUENCE OF 35-54.
TISSUE=Adrenal cortex;
PubMed=2738055 [NCBI, ExPASy, EBI, Israel, Japan]
Ogishima T.,
Mitani F.,
Ishimura Y.;
"Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex.";
J. Biol. Chem. 264:10935-10938(1989).
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- FUNCTION: Converts 11-deoxycorticosterone into corticosterone, 18-hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone.
- CATALYTIC ACTIVITY: A steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
- CATALYTIC ACTIVITY: Corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O.
- COFACTOR: Heme group (By similarity).
- SUBCELLULAR LOCATION: Mitochondrion membrane.
- TISSUE SPECIFICITY: Adrenal cortex.
- INDUCTION: A 12-fold increase was seen in the presence of a low sodium-high potassium diet.
- SIMILARITY: Belongs to the cytochrome P450 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 510 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58241 Da [This is the MW of the unprocessed precursor] |
CRC64: 2E5129EE513DEA9E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGACDNDFIE LHSRVTADVW LARPWQCLHR TRALGTTATL APKTLKPFEA IPQYSRNKWL
70 80 90 100 110 120
KMIQILREQG QENLHLEMHQ AFQELGPIFR HSAGGAQIVS VMLPEDAEKL HQVESILPRR
130 140 150 160 170 180
MHLEPWVAHR ELRGLRRGVF LLNGAEWRFN RLKLNPNVLS PKAVQNFVPM VDEVARDFLE
190 200 210 220 230 240
ALKKKVRQNA RGSLTMDVQQ SLFNYTIEAS NFALFGERLG LLGHDLNPGS LKFIHALHSM
250 260 270 280 290 300
FKSTTQLLFL PRSLTRWTST QVWKEHFDAW DVISEYANRC IWKVHQELRL GSSQTYSGIV
310 320 330 340 350 360
AALITQGALP LDAIKANSME LTAGSVDTTA IPLVMTLFEL ARNPDVQQAL RQETLAAEAS
370 380 390 400 410 420
IAANPQKAMS DLPLLRAALK ETLRLYPVGG FLERILNSDL VLQNYHVPAG TLVLLYLYSM
430 440 450 460 470 480
GRNPAVFPRP ERYMPQRWLE RKRSFQHLAF GFGVRQCLGR RLAEVEMLLL LHHMLKTFQV
490 500 510
ETLRQEDVQM AYRFVLMPSS SPVLTFRPIS
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P30099 in FASTA format |
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