[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=LTH677; PubMed=1575485 [NCBI, ExPASy, EBI, Israel, Japan] Knauf H.J., Vogel R.F., Hammes W.P.; "Cloning, sequence, and phenotypic expression of katA, which encodes the catalase of Lactobacillus sake LTH677."; Appl. Environ. Microbiol. 58:832-839(1992).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION. STRAIN=LTH677; PubMed=9546173 [NCBI, ExPASy, EBI, Israel, Japan] Hertel C., Schmidt G., Fischer M., Oellers K., Hammes W.P.; "Oxygen-dependent regulation of the expression of the catalase gene katA of Lactobacillus sakei LTH677."; Appl. Environ. Microbiol. 64:1359-1365(1998).

Comments

FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M84015; AAC19139.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T09652; T09652.

3D structure databases

HSSP

P42321; 1M85. [HSSP ENTRY / PDB]

ModBase

P30265.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 478`	`478`	`Catalase.`	`PRO_0000084989`
`ACT_SITE`	`53 53`		`By similarity.`
`ACT_SITE`	`126 126`		`By similarity.`
`METAL`	`336 336`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 478 AA [This is the length of the unprocessed precursor]

Molecular weight: 54076 Da [This is the MW of the unprocessed precursor]

CRC64: 85952A05DB16EF3D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTNQLTTNEG QPWADNQHSQ TAGQRGPVLI QDYQLLEKLA HFNRERIPER VVHAKGAGAK 

        70         80         90        100        110        120 
GYFKVTKDMS AYTKAAVFSG VGKKTPLITR FSQVAGEAGY PDTYRDVRGF AVKFYTEEGN 

       130        140        150        160        170        180 
YDIVGNNTPV FFVNDPLKFP DFIHSQKRDP RTHARSQDMQ WDFWSLSPES VHQVTILMSD 

       190        200        210        220        230        240 
RGIPASYRMM HGFGSHTFKW VNAQGEQFWV KYHFKTNQGI HNLSNELADE LAGKDTDYLQ 

       250        260        270        280        290        300 
NDLFDAIETG DYPSWTVAVQ LVPYEDGLNY PQDIFDVTKV ISQKDYPLIE IGQMVLDENP 

       310        320        330        340        350        360 
TNNFEDIQEL AFSPANLVPG IEASPDKLLQ GRLFGYKDAE RYRLGANYEQ LPVNRPKVPV 

       370        380        390        400        410        420 
HNYERDGAMA QNQATGVNYE PNSQDGPTEV PAAKIHGDQL SGTTGNFSAD PDYYSAAGKL 

       430        440        450        460        470 
YRLLSADEQT RLIENIRMNL GQVTKPEIQI REVKQFYQAD PEYGRRVATS VKLRFSSV

P30265 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools