ID DHSA_BOVIN Reviewed; 665 AA. AC P31039; Q9TUY8; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 16-AUG-2004, sequence version 3. DT 25-NOV-2008, entry version 79. DE RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; DE EC=1.3.5.1; DE AltName: Full=Flavoprotein subunit of complex II; DE Short=Fp; DE Flags: Precursor; GN Name=SDHA; Synonyms=SDH2, SDHFP1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. RC TISSUE=Heart; RX MEDLINE=92283874; PubMed=1375942; RA Birch-MacHin M.A., Farnsworth L., Ackrell B.A.C., Cochran B., RA Jackson S., Bindoff L.A., Aitken A., Diamond A.G., Turnbull D.M.; RT "The sequence of the flavoprotein subunit of bovine heart succinate RT dehydrogenase."; RL J. Biol. Chem. 267:11553-11558(1992). RN [2] RP SEQUENCE REVISION. RX MEDLINE=94190953; PubMed=8142412; DOI=10.1016/0005-2728(94)90203-8; RA Morris A.A.M., Farnsworth L., Ackrell B.A.C., Turnbull D.M., RA Birch-MacHin M.A.; RT "The cDNA sequence of the flavoprotein subunit of human heart RT succinate dehydrogenase."; RL Biochim. Biophys. Acta 1185:125-128(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-253. RC STRAIN=Hereford X Nelore; RX PubMed=10612251; RA Sonstegard T.S., Kappes S.M.; RT "Mapping of the SDHA locus to bovine chromosome 20."; RL Anim. Genet. 30:473-473(1999). CC -!- FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase CC (SDH) that is involved in complex II of the mitochondrial electron CC transport chain and is responsible for transferring electrons from CC succinate to ubiquinone (coenzyme Q). CC -!- CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol. CC -!- COFACTOR: FAD. CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. CC -!- SUBUNIT: Component of complex II composed of four subunits: the CC flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a CC cytochrome b560 composed of SDHC and SDHD. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral CC membrane protein; Matrix side. CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. CC FRD/SDH subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M60879; AAA30758.1; ALT_SEQ; mRNA. DR EMBL; AF139922; AAD38150.1; -; Genomic_DNA. DR PIR; A42792; A42792. DR RefSeq; NP_776603.1; -. DR UniGene; Bt.24449; -. DR HSSP; P10444; 1NEK. DR SMR; P31039; 55-665. DR GeneID; 281480; -. DR KEGG; bta:281480; -. DR HOVERGEN; P31039; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0050660; F:FAD binding; IEA:InterPro. DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:EC. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. DR InterPro; IPR003953; FAD_bind2_N. DR InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase. DR InterPro; IPR003952; FRD_SDH_FAD_BS. DR InterPro; IPR004112; Fum_Rdtase/Succ_DHase_flav_C. DR InterPro; IPR001100; Pyr_nuc-diS_OxRdtase. DR InterPro; IPR011281; Succ_DHase_flav_su_fwd. DR InterPro; IPR014006; Succ_Dhase_frdA_Gneg. DR Pfam; PF00890; FAD_binding_2; 1. DR Pfam; PF02910; Succ_DH_flav_C; 1. DR PRINTS; PR00368; FADPNR. DR PRINTS; PR00411; PNDRDTASEI. DR TIGRFAMs; TIGR01816; sdhA_forward; 1. DR TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1. DR PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1. PE 1: Evidence at protein level; KW Acetylation; Direct protein sequencing; Electron transport; FAD; KW Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; KW Oxidoreductase; Phosphoprotein; Transit peptide; Transport; KW Tricarboxylic acid cycle. FT TRANSIT 1 44 Mitochondrion. FT CHAIN 45 665 Succinate dehydrogenase [ubiquinone] FT flavoprotein subunit, mitochondrial. FT /FTId=PRO_0000010334. FT NP_BIND 92 107 FAD (By similarity). FT ACT_SITE 341 341 Proton acceptor (By similarity). FT BINDING 297 297 Substrate (By similarity). FT BINDING 309 309 Substrate (By similarity). FT BINDING 408 408 Substrate (By similarity). FT BINDING 452 452 Substrate (By similarity). FT MOD_RES 100 100 Tele-8alpha-FAD histidine (By FT similarity). FT MOD_RES 180 180 N6-acetyllysine (By similarity). FT MOD_RES 253 253 Phosphothreonine (By similarity). FT MOD_RES 486 486 N6-acetyllysine (By similarity). FT MOD_RES 499 499 N6-acetyllysine (By similarity). FT MOD_RES 539 539 N6-acetyllysine (By similarity). FT CONFLICT 242 253 DGSIHRIRARNT -> ERVHPPHQGQEH (in Ref. 3). SQ SEQUENCE 665 AA; 72944 MW; FE51160F248D51BC CRC64; MSGVAAVSRL WRARRLALTC TKWSAAWQTG TRSFHFTVDG NKRSSAKVSD AISAQYPVVD HEFDAVVVGA GGAGLRAAFG LSEAGFNTAC VTKLFPTRSH TVAAQGGINA ALGNMEEDNW RWHFYDTVKG SDWLGDQDAI HYMTEQAPAS VVELENYGMP FSRTEDGKIY QRAFGGQSLK FGKGGQAHRC CCVADRTGHS LLHTLYGRSL RYDTSYFVEY FALDLLMESG ECRGVIALCI EDGSIHRIRA RNTVIATGGY GRTYFSCTSA HTSTGDGTAM VTRAGLPCQD LEFVQFHPTG IYGAGCLITE GCRGEGGILI NSQGERFMER YAPVAKDLAS RDVVSRSMTL EIREGRGCGP EKDHVYLQLH HLPPAQLAMR LPGISETAMI FAGVDVTKEP IPVLPTVHYN MGGIPTNYKG QVLRHVNGQD QGVPGLYACG EAACASVHGA NRLGANSLLD LVVFGRACAL SIAESCRPGD KVPSIKPNAG EESVMNLDKL RFANGSIRTS ELRLNMQKSM QSHAAVFRVG SVLQEGCEKI SSLYGDLRHL KTFDRGMVWN TDLVETLELQ NLMLCALQTI YGAEARKESR GGPRREDFKE RVDEYDYSKP IQGQQKKPFE QHWRKHTLSY VDIKTGKVTL EYRPVIDRTL NETDCATVPP AIGSY //