ID   OXDD_BOVIN              Reviewed;         341 AA.
AC   P31228; O02846; Q9TRA3;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-NOV-2008, entry version 57.
DE   RecName: Full=D-aspartate oxidase;
DE            Short=DASOX;
DE            EC=1.4.3.1;
DE   AltName: Full=DDO;
GN   Name=DDO;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney cortex;
RX   MEDLINE=97220379; PubMed=9148742;
RA   Simonic T., Duga S., Negri A., Tedeschi G., Malcovati M.,
RA   Tenchini M.L., Ronchi S.;
RT   "cDNA cloning and expression of the flavoprotein D-aspartate oxidase
RT   from bovine kidney cortex.";
RL   Biochem. J. 322:729-735(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-338.
RC   TISSUE=Kidney;
RX   MEDLINE=92291057; PubMed=1601857;
RA   Negri A., Ceciliani F., Tedeschi G., Simonic T., Ronchi S.;
RT   "The primary structure of the flavoprotein D-aspartate oxidase from
RT   beef kidney.";
RL   J. Biol. Chem. 267:11865-11871(1992).
CC   -!- CATALYTIC ACTIVITY: D-aspartate + H(2)O + O(2) = oxaloacetate +
CC       NH(3) + H(2)O(2).
CC   -!- COFACTOR: FAD or 6-hydroxyflavin adenine dinucleotide.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the DAMOX/DASOX family.
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DR   EMBL; X95310; CAA64622.1; -; mRNA.
DR   PIR; A44132; A44132.
DR   RefSeq; NP_776333.1; -.
DR   UniGene; Bt.25930; -.
DR   HSSP; P00371; 1AN9.
DR   Ensembl; ENSBTAG00000033367; Bos taurus.
DR   GeneID; 280763; -.
DR   KEGG; bta:280763; -.
DR   HOVERGEN; P31228; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0003884; F:D-amino-acid oxidase activity; IEA:InterPro.
DR   GO; GO:0008445; F:D-aspartate oxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006181; D-amino_acid_oxidase_CS.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01266; DAO; 1.
DR   PROSITE; PS00677; DAO; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; FAD; Flavoprotein; Oxidoreductase;
KW   Peroxisome.
FT   CHAIN         1    341       D-aspartate oxidase.
FT                                /FTId=PRO_0000162769.
FT   NP_BIND       6     20       FAD (Potential).
FT   MOTIF       339    341       Microbody targeting signal (Potential).
FT   ACT_SITE    223    223       By similarity.
FT   ACT_SITE    302    302       By similarity.
FT   MOD_RES       1      1       Blocked amino end (Met).
FT   VARIANT     228    228       V -> I (in some molecules).
FT   CONFLICT    274    274       K -> R (in Ref. 2; AA sequence).
FT   CONFLICT    283    283       S -> G (in Ref. 2; AA sequence).
SQ   SEQUENCE   341 AA;  37660 MW;  355EF4EE42C53B49 CRC64;
     MDTVRIAVVG AGVMGLSTAV CISKMVPGCS ITVISDKFTP ETTSDVAAGM LIPPTYPDTP
     IQKQKQWFKE TFDHLFAIVN SAEAEDAGVI LVSGWQIFQS IPTEEVPYWA DVVLGFRKMT
     KDELKKFPQH VFGHAFTTLK CEGPAYLPWL QKRVKGNGGL ILTRRIEDLW ELHPSFDIVV
     NCSGLGSRQL AGDSKIFPVR GQVLKVQAPW VKHFIRDSSG LTYIYPGVSN VTLGGTRQKG
     DWNLSPDAEI SKEILSRCCA LEPSLRGAYD LREKVGLRPT RPSVRLEKEL LAQDSRRLPV
     VHHYGHGSGG IAMHWGTALE ATRLVNECVQ VLRTPAPKSK L
//