EC 1.12.98.2
H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase
N(5),N(10)-methenyltetrahydromethanopterin hydrogenase
H(2)-dependent methylene-H(4)MPT dehydrogenase

Gene name

Name:

hmd

From

Methanobacterium wolfei

[TaxID: 145261]

Taxonomy

Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.

Protein existence

1: Evidence at protein level;

References

[1]

PROTEIN SEQUENCE.
PubMed=1521540 [NCBI, ExPASy, EBI, Israel, Japan]
Zirngibl C., van Dongen W., Schwoerer B., von Buenau R., Richter M., Klein A., Thauer R.K.;
"H2-forming methylenetetrahydromethanopterin dehydrogenase, a novel type of hydrogenase without iron-sulfur clusters in methanogenic archaea.";
Eur. J. Biochem. 208:511-520(1992).

Comments

FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
CATALYTIC ACTIVITY: H₂ + 5,10-methenyltetrahydromethanopterin = H⁺ + 5,10-methylenetetrahydromethanopterin.
PATHWAY: One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methylene-H(4)MPT from 5,10-methenyl-H(4)MPT (hydrogen route): step 1/1 .
SIMILARITY: Belongs to the HMD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

ModBase

P32441.

Ontologies

GO:0047068;	Molecular function: N5,N10-methenyltetrahydromethanopterin hydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0015948;	Biological process: methanogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
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Family and domain databases

HAMAP

MF_01090; -; 1.
PBIL [Tree]

ProtoNet

P32441.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Methanogenesis; One-carbon metabolism; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 19`	`>19`	`5,10-methenyltetrahydromethanopterin hydrogenase.`	`PRO_0000218516`
`NON_TER`	`1 1`

Sequence information

Length: 19 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 1911 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 0C17E9D7BF1F97C9 [This is a checksum on the sequence]

        10 
MKLAILGAGC YRTDAASGI

P32441 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools