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UniProtKB/Swiss-Prot entry P32972

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TNFL8_MOUSE
Primary accession number P32972
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Tumor necrosis factor ligand superfamily member 8
Synonyms CD30 ligand
CD30-L
CD153 antigen
Gene name
Name: Tnfsf8
Synonyms: Cd30l, Cd30lg
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
DOI=10.1016/0092-8674(93)90361-S; PubMed=8391931 [NCBI, ExPASy, EBI, Israel, Japan]
Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S., Din W.S., Goodwin R.G., Armitage R.J.;
"CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.";
Cell 73:1349-1360(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L09754; AAA74595.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B40710; B40710.
RefSeq NP_033429.1; -.
UniGene Mm.4664
3D structure databases
ModBase P32972.
Organism-specific databases
MGI MGI:88328; Tnfsf8.
Gene expression databases
ArrayExpress P32972; -.
GermOnline ENSMUSG00000028362; Mus musculus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005164; Molecular function: tumor necrosis factor receptor binding (inferred from electronic annotation from InterPro).
GO:0006955; Biological process: immune response (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006052; TNF_family.
Graphical view of domain structure.
Pfam PF00229; TNF; 1.
Pfam graphical view of domain structure.
ProDom PD023087; TNF_8; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00207; TNF; 1.
SMART graphical view of domain structure.
PROSITE PS00251; TNF_1; 1.
PS50049; TNF_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P32972.
Genome annotation databases
Ensembl ENSMUSG00000028362; Mus musculus. [Contig view]
GeneID 21949; -.
KEGG mmu:21949; -.
Phylogenomic databases
HOGENOM P32972; -.
HOVERGEN P32972; -.
Other
NextBio 301608; -.
SOURCE Tnfsf8; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Glycoprotein; Membrane; Signal-anchor; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   239  239     Tumor necrosis factor ligand superfamily member 8. PRO_0000185500
TOPO_DOM   1    43  43     Cytoplasmic (Potential). 
TRANSMEM   44    67  24     Signal-anchor for type II membrane protein (Potential). 
TOPO_DOM   68   239  172     Extracellular (Potential). 
CARBOHYD   75    75        N-linked (GlcNAc...) (Potential). 
CARBOHYD   86    86        N-linked (GlcNAc...) (Potential). 
CARBOHYD   114   114        N-linked (GlcNAc...) (Potential). 
CARBOHYD   158   158        N-linked (GlcNAc...) (Potential). 
CARBOHYD   194   194        N-linked (GlcNAc...) (Potential). 
CARBOHYD   206   206        N-linked (GlcNAc...) (Potential). 
DISULFID   156   182        Potential. 
Sequence information
Length: 239 AA [This is the length of the unprocessed precursor] Molecular weight: 26519 Da [This is the MW of the unprocessed precursor] CRC64: 29003157DD425159 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT ALVCLVVAVA 

        70         80         90        100        110        120 
IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS KKSWAYLQVS KHLNNTKLSW 

       130        140        150        160        170        180 
NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT 

       190        200        210        220        230 
VCESGVQSKN IYQNLSQFLL HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD
P32972 in FASTA format

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