NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8226863 [NCBI, ExPASy, EBI, Israel, Japan]
Oestreicher N., Scazzocchio C.;
"Sequence, regulation, and mutational analysis of the gene encoding urate oxidase in Aspergillus nidulans.";
J. Biol. Chem. 268:23382-23389(1993).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC 4;
DOI=10.1038/nature04341; PubMed=16372000 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).

Comments

FUNCTION: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which spontaneously decomposes to form allantoin.
CATALYTIC ACTIVITY: Urate + O₂ + H₂O = 5-hydroxyisourate + H₂O₂.
PATHWAY: Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3 .
SUBCELLULAR LOCATION: Peroxisome.
SIMILARITY: Belongs to the uricase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X72210; CAA51009.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AACD01000194; EAA57588.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A48879; A48879.

RefSeq

XP_868852.1; -.

3D structure databases

HSSP

Q00511; 1UOX. [HSSP ENTRY / PDB]

SMR

P33282; 2-295.

ModBase

P33282.

Ontologies

GO:0005777;	Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004846;	Molecular function: urate oxidase activity (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006144;	Biological process: purine base metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002042; Uricase.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.270.10; Uricase; 1.

PANTHER

PTHR10395:SF1; Uricase; 1.

Pfam

PF01014; Uricase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00093; URICASE.

ProDom

PD003367; Uricase; 2.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03383; urate_oxi; 1.

PS00366; URICASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Oxidoreductase; Peroxisome; Purine metabolism.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 301`	`301`	`Uricase.`	`PRO_0000165996`
`MOTIF`	`299 301`	`3`	`Microbody targeting signal (Potential).`
`ACT_SITE`	`177 177`		`Charge relay system (By similarity).`
`ACT_SITE`	`229 229`		`Charge relay system (By similarity).`

Sequence information

Length: 301 AA [This is the length of the unprocessed precursor]

Molecular weight: 34003 Da [This is the MW of the unprocessed precursor]

CRC64: BA46DD84925BCD9F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTVAAARYG KDNVRVYKVH KDPKTGVQTV TEMTVCVLLE GEIDTSYTKA DNSVIVATDS 

        70         80         90        100        110        120 
IKNTIFILAK QNPVTPPELF GSILGTHFIN KYKHIHVAHT NIITHRWTRL NIDGKPHSHS 

       130        140        150        160        170        180 
FVRDSEETRN VQVDVTEGVG IDIKSSINKL TVLKSTGSQF WGFVRDEYTT LPEVWDRILS 

       190        200        210        220        230        240 
TDVEATWAWK RFSGLDEVRG NVPKFDETWE AARNITLKTF AEEESASVQA TMYKMGEQIL 

       250        260        270        280        290        300 
AYQPLLETVE YSLPNKHYFE IDLSWHKGLK NTGKDAEVFV PQTNPNGLIK CTVGRKSKAK 


L

P33282 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools