[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=India-1967 / Isolate Ind3; DOI=10.1016/0168-1702(93)90093-3; PubMed=8109158 [NCBI, ExPASy, EBI, Israel, Japan] Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Sandakhchiev L.S.; "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain."; Virus Res. 30:239-258(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=India-1967 / Isolate Ind3; DOI=10.1016/0014-5793(93)80041-R; PubMed=8384129 [NCBI, ExPASy, EBI, Israel, Japan] Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.; "Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms."; FEBS Lett. 319:80-83(1993).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Bangladesh-1975; DOI=10.1038/366748a0; PubMed=8264798 [NCBI, ExPASy, EBI, Israel, Japan] Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A., Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.; "Potential virulence determinants in terminal regions of variola smallpox virus genome."; Nature 366:748-751(1993).

Comments

FUNCTION: FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation (By similarity).
CATALYTIC ACTIVITY: 4 R'C(R)SH + O₂ = 2 R'C(R)S-S(R)CR' + 2 H₂O.
COFACTOR: FAD (By similarity).
SIMILARITY: Belongs to the poxviruses E10 family.
SIMILARITY: Contains 1 ERV/ALR sulfhydryl oxidase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X69198; CAA48992.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L22579; AAA60799.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A72157; A72157.
D36842; D36842.
T28489; T28489.

RefSeq

NP_042095.1; -.

3D structure databases

ModBase

P33821.

Ontologies

GO:0016972;	Molecular function: thiol oxidase activity (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006890; Pox_E10.
Graphical view of domain structure.

Pfam

PF04805; Pox_E10; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF015696; VAC_E10R; 1.

PROSITE

PS51324; ERV_ALR; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P33821.

Genome annotation databases

GeneID

1486405; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 95`	`95`	`Probable FAD-linked sulfhydryl oxidase E10.`	`PRO_0000099466`
`DOMAIN`	`1 95`	`95`	`ERV/ALR sulfhydryl oxidase.`
`DISULFID`	`43 46`		`Redox-active (Potential).`

Sequence information

Length: 95 AA [This is the length of the unprocessed precursor]

Molecular weight: 10836 Da [This is the MW of the unprocessed precursor]

CRC64: 9BCB0B4306397E27 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNPKHWGRAA WTIIFIVLSQ AGLDGNIEAC KRKLYTIVST LPCPACRRHA TIAIEDNNIM 

        70         80         90 
SSNDLNYIYY FFIRLFNNLA SDPKYAIDVS KVKPL

P33821 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools