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UniProtKB/Swiss-Prot entry P34136


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH2_DICDI
Primary accession number P34136
Secondary accession number Q551D5
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on December 4, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms HMG-CoA reductase 2
EC 1.1.1.34
Gene name
Name: hmgB
ORFNames: DDB_0215357
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 46-526.
STRAIN=AX3;
De Lozanne A.;
"The dictyostelium HMGCoA reductase genes.";
Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000016; EAL69120.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L19350; AAA33215.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_643058.1; -.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase P34136.
Organism-specific databases
dictyBase DDB0215357; hmgB.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 2.
PANTHER PTHR10572; HMG-CoA_red; 2.
Pfam PF00368; HMG-CoA_red; 2.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P34136.
Genome annotation databases
GeneID 3394199; -.
KEGG ddi:DDB_0215357; -.
Other
ProtoNet P34136.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Complete proteome; Lipid synthesis; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   526  526     3-hydroxy-3-methylglutaryl-coenzyme A reductase 2. PRO_0000114428
ACT_SITE   193   193        Charge relay system (By similarity). 
ACT_SITE   325   325        Charge relay system (By similarity). 
ACT_SITE   401   401        Charge relay system (By similarity). 
ACT_SITE   499   499        Proton donor (By similarity). 
Sequence information
Length: 526 AA [This is the length of the unprocessed precursor] Molecular weight: 56160 Da [This is the MW of the unprocessed precursor] CRC64: 5C95CCBB7180EC92 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIRIGSNLIK QSIKNTNKSG ISRFFTTGSN NSTNYKPESC VKEEPKGKSV NVEDLKDQEI 

        70         80         90        100        110        120 
IALVDKGEIQ PHNLETRLPN NFQRAVHIRR KLLARDLQKE HQRALHAQAV VAAAEKAATS 

       130        140        150        160        170        180 
GEDPSSIQPV VPPTSNLDFE GSLTNLPVDH FDYTKVLGAC CENVIGYIPI PVGVAGPILL 

       190        200        210        220        230        240 
DGKLVSIPMA TTEGCLVAST HRGAKAITKS GGAKTVLLQS GMTRAPVCRL PSSIRAGELK 

       250        260        270        280        290        300 
QWIENQENFY QVASAFNSTS RFARLKSIKV VIAGRLVYLR FKSSTGDAMG MNMVSKGVEK 

       310        320        330        340        350        360 
ALEVITEYFP EMEVLSLSGN VCTDKKPSSI NWLEGRGKSV VAEAVISGDI VRDVLKTTVE 

       370        380        390        400        410        420 
ALVSLNIDKN LIGSAMAGSI GGFNAHASNI VTALYIATGQ DPAQNVESSN CITLMESING 

       430        440        450        460        470        480 
GKDLYISVTM PSIEVGTVGG GTHLPAQSAC LDLLKIRGAN LERPGANSEQ LARVVAAAVL 

       490        500        510        520 
SGELSLMSAL AAGHLVRSHL KHNRKTEAPA PQADTISMTH NLPHSD 

P34136 in FASTA format

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