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UniProtKB/Swiss-Prot entry P34188

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_CROLA
Primary accession number P34188
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on February 1, 1994 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: mt-co1
Synonyms: coi, coxi, mtco1
From
Crossostoma lacustre (Oriental stream loach) [TaxID: 7980] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Balitoridae; Balitorinae; Crossostoma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Oocyte;
DOI=10.1093/nar/20.18.4853; PubMed=1408800 [NCBI, ExPASy, EBI, Israel, Japan]
Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.;
"The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates.";
Nucleic Acids Res. 20:4853-4858(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M91245; AAB96813.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S35464; S35464.
RefSeq NP_008305.1; -.
3D structure databases
HSSP P00396; 2OCC. [HSSP ENTRY / PDB]
SMR P34188; 1-514.
ModBase P34188.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P34188.
Genome annotation databases
GeneID 807987; -.
Phylogenomic databases
HOVERGEN P34188; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   516  516     Cytochrome c oxidase subunit 1. PRO_0000183318
TRANSMEM   17    37  21     Potential. 
TRANSMEM   56    76  21     Potential. 
TRANSMEM   102   122  21     Potential. 
TRANSMEM   145   165  21     Potential. 
TRANSMEM   183   203  21     Potential. 
TRANSMEM   234   254  21     Potential. 
TRANSMEM   268   288  21     Potential. 
TRANSMEM   310   330  21     Potential. 
TRANSMEM   338   358  21     Potential. 
TRANSMEM   380   400  21     Potential. 
TRANSMEM   414   434  21     Potential. 
TRANSMEM   456   476  21     Potential. 
METAL   61    61        Iron (heme A axial ligand) (Probable). 
METAL   240   240        Copper B (Probable). 
METAL   244   244        Copper B (Probable). 
METAL   290   290        Copper B (Probable). 
METAL   291   291        Copper B (Probable). 
METAL   376   376        Iron (heme A3 axial ligand) (Probable). 
METAL   378   378        Iron (heme A axial ligand) (Probable). 
CROSSLNK   240   244        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
Sequence information
Length: 516 AA [This is the length of the unprocessed precursor] Molecular weight: 56953 Da [This is the MW of the unprocessed precursor] CRC64: E5DBD18C495E9167 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAITRWFFST NHKDIGTLYL VFGAWAGMVG TALSLLIRAE LNQPGALLGD DQIYNVIVTA 

        70         80         90        100        110        120 
HAFVMIFFMV MPILIGGFGN WLVPLMIGAP HMAFPRMNNM SFWLLPPSFL LLLASSGVEA 

       130        140        150        160        170        180 
GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTTIN MKPPALSQYQ 

       190        200        210        220        230        240 
TPLFVWAVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGIISHVVAY YAGKKEPFGY MGMVWAMMAI GLLGFIVWAH HMFTVGMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGVKV FSWLATLHGG TIKWDTPMLW ALGFIFLFTV GGLTGIVLSN 

       370        380        390        400        410        420 
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF TGFSLHDTWT KIHFGVMFIG 

       430        440        450        460        470        480 
VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW NTVSSIGSLI SLVAVIIFLF ILWEAFASKR 

       490        500        510 
QVMSVELTMT NVEWLHGCPP PYHTFEEPAF VQVRSN
P34188 in FASTA format

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