ID   IVD_CAEEL               Reviewed;         408 AA.
AC   P34275;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 2.
DT   25-NOV-2008, entry version 70.
DE   RecName: Full=Probable isovaleryl-CoA dehydrogenase;
DE            Short=IVD;
DE            EC=1.3.99.10;
GN   ORFNames=C02D5.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=94150718; PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
RA   Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
RA   Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
RA   Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
RA   Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
RA   Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
RA   Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
RA   Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
RA   Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
RA   Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
RA   Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-
CC       2-enoyl-CoA + reduced acceptor.
CC   -!- COFACTOR: FAD.
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; HMG-CoA
CC       from 3-isovaleryl-CoA: step 1/3.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR   EMBL; L16622; AAA27913.2; -; Genomic_DNA.
DR   PIR; S44743; S44743.
DR   RefSeq; NP_498885.1; -.
DR   UniGene; Cel.10914; -.
DR   HSSP; P15651; 1JQI.
DR   Ensembl; C02D5.1; Caenorhabditis elegans.
DR   GeneID; 182112; -.
DR   KEGG; cel:C02D5.1; -.
DR   NMPDR; fig|6239.3.peg.10888; -.
DR   WormBase; WBGene00015335; C02D5.1.
DR   WormPep; C02D5.1; CE24778.
DR   NextBio; 916428; -.
DR   ArrayExpress; P34275; -.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006091; Acyl-CoA_DHase/Oxase_M.
DR   InterPro; IPR006089; Acyl-CoA_DHase_CS.
DR   InterPro; IPR006092; Acyl-CoA_DHase_N.
DR   InterPro; IPR006090; Acyl-CoA_Oxase/DHase_1.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR   PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    408       Probable isovaleryl-CoA dehydrogenase.
FT                                /FTId=PRO_0000201191.
FT   ACT_SITE    265    265       Proton acceptor (By similarity).
SQ   SEQUENCE   408 AA;  45326 MW;  A6351C6DCDCA962D CRC64;
     MAFLARKTSS LLPATTSSTV KHMIYDEPHF AMQNSLAKLI KEKINPNVAQ WEKSGRYPAH
     FVFKMLGQLG VFAVNKPVDY GGTGRDFAMS IAIAEQIGAV DCGSIPMSVM VQSDMSTPAL
     AQFGSDSLRN RFLRPSINGD LVSSIAVSEP HAGSDVSAIR THARRYGSDL IINGSKMWIT
     NGDQADWACV LVNTSNAKNL HKNKSLVCIP LDSIGVHRST PLDKLGMRSS DTVQLFFEDV
     RVPSSYIIGE EGRGFAYQMN QFNDERLVTV AVGLLPLQKC INETIEYARE RLIFGKTLLD
     QQYVQFRLAE LEAELEATRS LLYRTVLARC QGEDVSMLTA MAKLKIGRLA RKVTDQCLQI
     WGGAGYLNDN GISRAFRDFR IFSIGAGCDE VMMQIIHKTQ SKRQQKRI
//