[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Root nodule; Bang K.H., An C.S.; "Nucleotide sequence and expression of cDNA clones encoding uricase II in Canavalia lineata."; Singmul Hakhoe Chi 36:415-423(1993).

Comments

FUNCTION: Catalyzes the oxidation of uric acid to 5-hydroxyisourate which spontaneously decompose to form allantoin (By similarity).
CATALYTIC ACTIVITY: Urate + O₂ + H₂O = 5-hydroxyisourate + H₂O₂.
PATHWAY: Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3 .
SUBCELLULAR LOCATION: Peroxisome (By similarity).
SIMILARITY: Belongs to the uricase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X76286; CAA53904.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S38911; S38911.

3D structure databases

HSSP

Q00511; 1UOX. [HSSP ENTRY / PDB]

ModBase

P34798.

Ontologies

GO:0005777;	Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004846;	Molecular function: urate oxidase activity (inferred from electronic annotation from InterPro).
GO:0009877;	Biological process: nodulation (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006144;	Biological process: purine base metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002042; Uricase.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.270.10; Uricase; 1.

PANTHER

PTHR10395:SF1; Uricase; 1.

Pfam

PF01014; Uricase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00093; URICASE.

ProDom

PD003367; Uricase; 2.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03383; urate_oxi; 1.

PS00366; URICASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Nodulation; Oxidoreductase; Peroxisome; Purine metabolism.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 308`	`308`	`Uricase-2 isozyme 1.`	`PRO_0000166000`
`MOTIF`	`306 308`	`3`	`Microbody targeting signal (Potential).`
`ACT_SITE`	`182 182`		`Charge relay system (By similarity).`
`ACT_SITE`	`238 238`		`Charge relay system (By similarity).`

Sequence information

Length: 308 AA [This is the length of the unprocessed precursor]

Molecular weight: 34943 Da [This is the MW of the unprocessed precursor]

CRC64: 2968988B6FA1993D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAKEIVGGFK FDQRHGKERV QVARVWKTKQ GWYFIVEWRV GNSLLSDCVN SYVRDDNSDI 

        70         80         90        100        110        120 
VATDTMKNTV YAKAKECSEI LSVEDFAILL AKHFISFYKQ VTAAIVNIVE KPWERVSVDG 

       130        140        150        160        170        180 
QPHEHGFKLG SERHTAEAIV QKSGALQLTS GIEGLSLLKT TKSGFEGFIR DKYTALPETH 

       190        200        210        220        230        240 
ERMLATEVTA LWRYSYESLY SIPQKPLYFT DKYLEVKKVL ADNFFGPPNV GVYSPSVQNT 

       250        260        270        280        290        300 
LYLMAKAALN RFPEIASIQL KMPNIHFLPV NISNKDGPIV KFEADVYLPT DEPHGSIQAS 


LRRLWSKL

P34798 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools