ID   G3PC_PHYPA              Reviewed;         342 AA.
AC   P34923;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-NOV-2008, entry version 54.
DE   RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase, cytosolic;
DE            EC=1.2.1.12;
GN   Name=GAPC;
OS   Physcomitrella patens (Moss).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Moss Superclass V; Bryopsida; Funariidae; Funariales; Funariaceae;
OC   Physcomitrella.
OX   NCBI_TaxID=3218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93196483; PubMed=8095691;
RA   Martin W., Lydiate D., Brinkmann H., Forkmann G., Saedler H.,
RA   Cerff R.;
RT   "Molecular phylogenies in angiosperm evolution.";
RL   Mol. Biol. Evol. 10:140-162(1993).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate + phosphate +
CC       NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; X72381; CAA51071.1; -; mRNA.
DR   HSSP; P56649; 1DSS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000173; GlycerAld_3-P_DHase.
DR   InterPro; IPR006424; Glyceraldehyde-3-P_DHase_1.
DR   PANTHER; PTHR10836; GAP_DH; 1.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   PIRSF; PIRSF000149; GAP_DH; 1.
DR   PRINTS; PR00078; G3PDHDRGNASE.
DR   TIGRFAMs; TIGR01534; GAPDH-I; 1.
DR   PROSITE; PS00071; GAPDH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Glycolysis; NAD; Oxidoreductase.
FT   CHAIN         1    342       Glyceraldehyde-3-phosphate dehydrogenase,
FT                                cytosolic.
FT                                /FTId=PRO_0000145613.
FT   NP_BIND      16     17       NAD (By similarity).
FT   REGION      155    157       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   REGION      215    216       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   ACT_SITE    156    156       Nucleophile (By similarity).
FT   BINDING      38     38       NAD (By similarity).
FT   BINDING      85     85       NAD; via carbonyl oxygen (By similarity).
FT   BINDING     186    186       Glyceraldehyde 3-phosphate (By
FT                                similarity).
FT   BINDING     238    238       Glyceraldehyde 3-phosphate (By
FT                                similarity).
FT   BINDING     320    320       NAD (By similarity).
FT   SITE        183    183       Activates thiol group during catalysis
FT                                (By similarity).
SQ   SEQUENCE   342 AA;  36762 MW;  F15CD336F1E4CFCA CRC64;
     MVGSAKIKVG INGFGRIGRL VARVALERDD IELVAINDPF ITPEYMTYMF KYDSTHGQWK
     KTEVTLHSEG HLTFGGNPVA VYACRDPSEI PWGKHGADFV VESTGVFTDK DKAAAHLKGG
     AKKVVISAPS KDAPMFVMGV NENKYSDEDI VSNASCTTNC LAPLAKVIND KFGILEGLMT
     TVHATTATQK TVDGPSSKDW RGGRSAATNI IPSATGAAKA VGKVLPELNG KLTGMAFRVP
     TTDVSVVDLT VRLEKPASYD AIKTAIKEAS EGQMKGILGY TEDDVVSTDF ITDSRSSIFD
     AKAGIALSDT FVKLVAWYDN EWGYSNRVVD LIVHMAKQGT SQ
//