ID   ODPA_ACHLA              Reviewed;         345 AA.
AC   P35485;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   04-NOV-2008, entry version 41.
DE   RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha;
DE            EC=1.2.4.1;
DE   Flags: Fragment;
GN   Name=pdhA;
OS   Acholeplasma laidlawii.
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Acholeplasma.
OX   NCBI_TaxID=2148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=92138635; PubMed=1735725;
RA   Wallbrandt P., Tegman V., Jonsson B.-H., Wieslander A.;
RT   "Identification and analysis of the genes coding for the putative
RT   pyruvate dehydrogenase enzyme complex in Acholeplasma laidlawii.";
RL   J. Bacteriol. 174:1388-1396(1992).
CC   -!- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall
CC       conversion of pyruvate to acetyl-CoA and CO(2). It contains
CC       multiple copies of three enzymatic components: pyruvate
CC       dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and
CC       lipoamide dehydrogenase (E3).
CC   -!- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue
CC       acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue
CC       acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Thiamine pyrophosphate.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
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DR   EMBL; M81753; AAA21907.1; -; Genomic_DNA.
DR   PIR; A42653; A42653.
DR   HSSP; P12694; 1DTW.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring...; IEA:EC.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001017; DHase_E1.
DR   InterPro; IPR017596; Pyrv_DH_E1_asu_subgrp-x.
DR   Pfam; PF00676; E1_dh; 1.
PE   4: Predicted;
KW   Glycolysis; Oxidoreductase; Pyruvate; Thiamine pyrophosphate.
FT   CHAIN        <1    345       Pyruvate dehydrogenase E1 component
FT                                subunit alpha.
FT                                /FTId=PRO_0000162197.
FT   NON_TER       1      1
SQ   SEQUENCE   345 AA;  38962 MW;  797F9F67DE0C2995 CRC64;
     DQNGKVVNEK MEPKLPKETL LKMYKTAVLG RNADIKALQY QRQGRMLTYA PNMGQEAAQI
     GMAAAMEPQD WNSPMYRELN TLLYRGDKLE NVFLYWYGNE RGSIKPEGVK ILPTNIIIGS
     QSNIAAGLAM ASKIRKTNEV TAFTIGDGGT AHGEFYEGLN FAASFKAPVV AVIQNNQWAI
     STPVRKASNS ETLAQKGVAF GIPYIQVDGN DMLAMYVASK EAMDRARKGD GPTLIEAFTY
     RMGPHTTSDD PCSIYRTKEE ENEWAKKDQI ARFKTYLINK GYWSEEEDKK LEEEVLAEIN
     DTFKKVESYG ANVELIEIFE HTYAEMTPQL KEQYEEHKKY LEGVK
//