ID   DHSO1_YEAST             Reviewed;         357 AA.
AC   P35497;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-NOV-2008, entry version 73.
DE   RecName: Full=Sorbitol dehydrogenase 1;
DE            EC=1.1.1.14;
DE   AltName: Full=L-iditol 2-dehydrogenase 1;
GN   Name=SOR1; Synonyms=SDH1; OrderedLocusNames=YJR159W; ORFNames=J2395;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94171068; PubMed=8125328; DOI=10.1016/0378-1119(94)90741-2;
RA   Sarthy A.V., Schopp C., Idler K.B.;
RT   "Cloning and sequence determination of the gene encoding sorbitol
RT   dehydrogenase from Saccharomyces cerevisiae.";
RL   Gene 140:121-126(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   MEDLINE=96208490; PubMed=8641269;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N.,
RA   Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H.,
RA   Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A.,
RA   Hennemann A., Herbert C.J., Heumann K., Hilger F., Hollenberg C.P.,
RA   Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L.,
RA   Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V.,
RA   Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M.,
RA   Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W.,
RA   Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M.,
RA   Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A.,
RA   Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M.,
RA   Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- CATALYTIC ACTIVITY: L-iditol + NAD(+) = L-sorbose + NADH.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; L11039; AAA35027.1; -; Genomic_DNA.
DR   EMBL; Z49659; CAA89692.1; -; Genomic_DNA.
DR   EMBL; AY693012; AAT93031.1; -; Genomic_DNA.
DR   PIR; S55941; S55941.
DR   RefSeq; NP_012693.1; -.
DR   HSSP; O96496; 1E3J.
DR   DIP; DIP:1511N; -.
DR   IntAct; P35497; -.
DR   Ensembl; YJR159W; Saccharomyces cerevisiae.
DR   GeneID; 853624; -.
DR   GenomeReviews; Y13136_GR; YJR159W.
DR   KEGG; sce:YJR159W; -.
DR   NMPDR; fig|4932.3.peg.3671; -.
DR   CYGD; YJR159w; -.
DR   SGD; S000003920; SOR1.
DR   HOGENOM; P35497; -.
DR   LinkHub; P35497; -.
DR   NextBio; 974490; -.
DR   GermOnline; YJR159W; Saccharomyces cerevisiae.
DR   GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0019318; P:hexose metabolic process; IEP:SGD.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR013154; AlcDHase_GroES-like.
DR   InterPro; IPR002085; AlcDHase_SF_Zn.
DR   InterPro; IPR013149; AlcDHase_Zn-bd.
DR   InterPro; IPR002328; AlcDHase_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   ProDom; PD040557; GroES_related; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   CHAIN         1    357       Sorbitol dehydrogenase 1.
FT                                /FTId=PRO_0000160821.
FT   METAL        43     43       Zinc; catalytic (By similarity).
FT   METAL        68     68       Zinc; catalytic (By similarity).
FT   METAL        69     69       Zinc; catalytic (By similarity).
SQ   SEQUENCE   357 AA;  38166 MW;  16843C2040A3334A CRC64;
     MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY RSGGIGKYIL
     KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY SDETKEGRYN LCPHMAFAAT
     PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG
     PVGLLTGAVA RAFGATDVIF VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL
     LGGNHADVVF ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF
     RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK TIIFGPE
//