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UniProtKB/Swiss-Prot entry P35596

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLPO_STRPN
Primary accession number P35596
Secondary accession number O87017
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on September 26, 2001 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 62)
Name and origin of the protein
Protein name Alpha-glycerophosphate oxidase
Synonyms EC 1.1.3.21
Glycerol-3-phosphate oxidase
Exported protein 6
Gene name
Name: glpO
Synonyms: exp6
OrderedLocusNames: SP_2185
From
Streptococcus pneumoniae [TaxID: 1313] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 27336;
DOI=10.1074/jbc.273.37.23812; PubMed=9726992 [NCBI, ExPASy, EBI, Israel, Japan]
Parsonage D., Luba J., Mallett T.C., Claiborne A.;
"The soluble alpha-glycerophosphate oxidase from Enterococcus casseliflavus. Sequence homology with the membrane-associated dehydrogenase and kinetic analysis of the recombinant enzyme.";
J. Biol. Chem. 273:23812-23822(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-334 / TIGR4;
DOI=10.1126/science.1061217; PubMed=11463916 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.";
Science 293:498-506(2001).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 271-408.
STRAIN=R6x;
DOI=10.1111/j.1365-2958.1993.tb01233.x; PubMed=7934910 [NCBI, ExPASy, EBI, Israel, Japan]
Pearce B.J., Yin Y.B., Masure H.R.;
"Genetic identification of exported proteins in Streptococcus pneumoniae.";
Mol. Microbiol. 9:1037-1050(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U94770; AAC34740.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE005672; AAK76236.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L20560; AAA26882.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C95255; C95255.
RefSeq NP_346596.1; -.
3D structure databases
ModBase P35596.
Ontologies
GO
GO:0009331; Cellular component: glycerol-3-phosphate dehydrogenase complex (inferred from electronic annotation from InterPro).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004368; Molecular function: glycerol-3-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0004369; Molecular function: glycerol-3-phosphate oxidase activity (inferred from electronic annotation from EC).
GO:0006072; Biological process: glycerol-3-phosphate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000447; FAD-dep_Gly3P_DHase.
IPR006076; FAD-dep_OxRdtase.
Graphical view of domain structure.
Pfam PF01266; DAO; 1.
Pfam graphical view of domain structure.
PRINTS PR01001; FADG3PDH.
PROSITE PS00977; FAD_G3PDH_1; 1.
PS00978; FAD_G3PDH_2; FALSE_NEG.
ProtoNet P35596.
Genome annotation databases
GeneID 930187; -.
GenomeReviews AE005672_GR; SP_2185.
KEGG spn:SP_2185; -.
TIGR SP_2185; -.
Phylogenomic databases
HOGENOM P35596; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; FAD; Flavoprotein; Glycerol metabolism; Membrane; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   608  608     Alpha-glycerophosphate oxidase. PRO_0000126108
NP_BIND   21    49  29     FAD (Potential). 
CONFLICT   100   100        S -> P (in Ref. 1; AAC34740). 
CONFLICT   138   138        A -> T (in Ref. 1; AAC34740). 
CONFLICT   275   275        Y -> S (in Ref. 3; AAA26882). 
CONFLICT   367   367        S -> R (in Ref. 3; AAA26882). 
CONFLICT   544   544        T -> A (in Ref. 1; AAC34740). 
CONFLICT   572   572        I -> V (in Ref. 1; AAC34740). 
Sequence information
Length: 608 AA [This is the length of the unprocessed precursor] Molecular weight: 66796 Da [This is the MW of the unprocessed precursor] CRC64: A29B42FF4A75E406 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEFSKKTREL SIKKMQERTL DLLIIGGGIT GAGVALQAAA SGLETGLIEM QDFAEGTSSR 

        70         80         90        100        110        120 
STKLVHGGLR YLKQFDVEVV SDTVSERAVV QQIAPHIPKS DPMLLPVYDE DGATFSLFRL 

       130        140        150        160        170        180 
KVAMDLYDLL AGVSNTPAAN KVLSKDQVLE RQPNLKKEGL VGGGVYLDFR NNDARLVIEN 

       190        200        210        220        230        240 
IKRANQDGAL IANHVKAEGF LFDESGKITG VVARDLLTDQ VFEIKARLVI NTTGPWSDKV 

       250        260        270        280        290        300 
RNLSNKGTQF SQMRPTKGVH LVVDSSKIKV SQPVYFDTGL GDGRMVFVLP RENKTYFGTT 

       310        320        330        340        350        360 
DTDYTGDLEH PKVTQEDVDY LLGIVNNRFP ESNITIDDIE SSWAGLRPLI AGNSASDYNG 

       370        380        390        400        410        420 
GNNGTISDES FDNLIATVES YLSKEKTRED VESAVSKLES STSEKHLDPS AVSRGSSLDR 

       430        440        450        460        470        480 
DDNGLLTLAG GKITDYRKMA EGAMERVVDI LKAEFDRSFK LINSKTYPVS GGELNPANVD 

       490        500        510        520        530        540 
SEIEAFAQLG VSRGLDSKEA HYLANLYGSN APKVFALAHS LEQAPGLSLA DTLSLHYAMR 

       550        560        570        580        590        600 
NELTLSPVDF LLRRTNHMLF MRDSLDSIVE PILDEMGRFY DWTEEEKATY RADVEAALAN 


NDLAELKN
P35596 in FASTA format

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