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- FUNCTION: Could inhibit the oxidative burst of leukocytes and neutralize the secondary products of lipid peroxidation, thus providing the resistance of these parasites to immune effector mechanisms and their persistence in the mammalian host. It may also be involved in the formation of cross-linking residues such as dityrosine, trityrosine and isotrityrosine identified in cuticular collagen. Highly cross-linked external cortex may also serve to protect the parasite from immune attack.
- CATALYTIC ACTIVITY: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
- SUBUNIT: Homotetramer.
- SUBCELLULAR LOCATION: Secreted. Note=Secreted into the cuticle and ultimately released into the medium.
- DEVELOPMENTAL STAGE: Up-regulated in the third stage larvae following infection of host. Concomitant synthesis occurs at a high level through the adult stage. Not detected in microfilariae.
- SIMILARITY: Belongs to the glutathione peroxidase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 223 AA [This is the length of the unprocessed precursor] |
Molecular weight: 25845 Da [This is the MW of the unprocessed precursor] |
CRC64: 0709C754B99A1EF2 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSAQLLILSH VVLLQLIVAQ LGPKIGKQFL KPKQCEITNQ TVYDFHAQML NGAQRSLTEY
70 80 90 100 110 120
RNKVLLIVNV ATYCAYTMQY RDFNPILGSN SNGTLNILGF PCNQFYLQEP AENHELLNGL
130 140 150 160 170 180
KYVRPGHGWE PHKNMHIFGK LEVNGENDHP LYKFLKERCP PTVPVIGKRH QLIYDPIGTN
190 200 210 220
DVIWNFEKFL VDKKGRPRYR FHPENWVQGT AVKPYIDELE REI
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P35666 in FASTA format |
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