ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P36552


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name HEM6_MOUSE
Primary accession number P36552
Secondary accession numbers Q7TQ36 Q8VD08
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 21, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 78)
Name and origin of the protein
Protein name Coproporphyrinogen III oxidase, mitochondrial [Precursor]
Synonyms Coproporphyrinogenase
Coprogen oxidase
COX
EC 1.3.3.3
Gene name
Name: Cpox
Synonyms: Cpo
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8407975 [NCBI, ExPASy, EBI, Israel, Japan]
Kohno H., Furukawa T., Yoshinaga T., Tokunaga R., Taketani S.;
"Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation.";
J. Biol. Chem. 268:21359-21363(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139.
DOI=10.1042/BJ20040570; PubMed=15482256 [NCBI, ExPASy, EBI, Israel, Japan]
Dailey T.A., Woodruff J.H., Dailey H.A.;
"Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase.";
Biochem. J. 386:381-386(2005).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144.
DOI=10.1620/tjem.200.39; PubMed=12862310 [NCBI, ExPASy, EBI, Israel, Japan]
Susa S., Daimon M., Ono H., Li S., Yoshida T., Kato T.;
"The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria.";
Tohoku J. Exp. Med. 200:39-45(2003).
[5]
PROTEIN SEQUENCE OF 99-125 AND 248-258.
PubMed=8159699 [NCBI, ExPASy, EBI, Israel, Japan]
Martasek P., Camadro J.-M., Delfau-Larue M.H., Dumas J.B., Montagne J.J., de Verneuil H., Labbe P., Grandchamp B.;
"Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase.";
Proc. Natl. Acad. Sci. U.S.A. 91:3024-3028(1994).
[6]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-360, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D16333; BAA03840.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC017680; AAH17680.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY382578; AAQ88103.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB099924; BAC79229.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A48049; A48049.
RefSeq NP_031783.2; -.
UniGene Mm.291519
3D structure databases
SMR P36552; 110-442.
ModBase P36552.
PTM databases
PhosphoSite P36552; -.
Organism-specific databases
MGI MGI:104841; Cpox.
Gene expression databases
ArrayExpress P36552; -.
CleanEx MM_CPOX; -.
GermOnline ENSMUSG00000022742; Mus musculus.
Ontologies
GO
GO:0005758; Cellular component: mitochondrial intermembrane space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004109; Molecular function: coproporphyrinogen oxidase activity (inferred from electronic annotation from InterPro).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001260; Coprogen_oxidas.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
PANTHER PTHR10755; Coprogen_oxidas; 1.
Pfam PF01218; Coprogen_oxidas; 1.
Pfam graphical view of domain structure.
PRINTS PR00073; COPRGNOXDASE.
PROSITE PS01021; COPROGEN_OXIDASE; 1.
ProtoNet P36552.
Genome annotation databases
Ensembl ENSMUSG00000022742; Mus musculus. [Contig view]
GeneID 12892; -.
KEGG mmu:12892; -.
NMPDR fig|10090.3.peg.31449; -.
Phylogenomic databases
HOGENOM P36552; -.
HOVERGEN P36552; -.
Other
NextBio 282498; -.
SOURCE Cpox; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; Heme biosynthesis; Mitochondrion; Oxidoreductase; Phosphoprotein; Porphyrin biosynthesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    98  98     Mitochondrion. 
CHAIN   99   443  345     Coproporphyrinogen III oxidase, mitochondrial. PRO_0000006030
MOD_RES   99    99        Phosphoserine. 
MOD_RES   360   360        N6-acetyllysine. 
CONFLICT   7     7        R -> P (in Ref. 1; BAA03840). 
CONFLICT   101   101        S -> T (in Ref. 5; AA sequence). 
CONFLICT   116   117        CS -> SD (in Ref. 5; AA sequence). 
CONFLICT   122   122        S -> T (in Ref. 5; AA sequence). 
CONFLICT   124   124        V -> P (in Ref. 5; AA sequence). 
CONFLICT   138   138        K -> N (in Ref. 3; BAC79229). 
CONFLICT   275   275        T -> R (in Ref. 1; BAA03840). 
Sequence information
Length: 443 AA [This is the length of the unprocessed precursor] Molecular weight: 49715 Da [This is the MW of the unprocessed precursor] CRC64: 9F3D5E8E420645F0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALRLGRLGS DPWWRAVLGD YAQLRAASPR CASARVCQLP GTAGPQPRRG LGYGPWARGG 

        70         80         90        100        110        120 
SGLGTRLAAT LAGLAGLAAA AFGHVQRAEM VPKSSGARSP SPGRREEDGD ELARRCSTFM 

       130        140        150        160        170        180 
SSPVTELREL RRRPEDMKTK MELMIMETQA QVCRALAQVD GVADFTVDRW ERKEGGGGIT 

       190        200        210        220        230        240 
CVLQDGRVFE KAGVSISVVH GNLSEEAANQ MRGRGKTLKT KDSKLPFTAM GVSSVIHPKN 

       250        260        270        280        290        300 
PYAPTMHFNY RYFEVEEADG NTHWWFGGGC DLTPTYLNQE DAVHFHRTLK EACDQHGPDI 

       310        320        330        340        350        360 
YPKFKKWCDD YFFIVHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 

       370        380        390        400        410        420 
HCDDSYTPRD KLWQQLRRGR YVEFNLLYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 

       430        440 
SPPENSKEAE ILEVLRHPKD WVH 

P36552 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!