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UniProtKB/Swiss-Prot entry P36553


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM6_ECOLI
Primary accession number P36553
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 69)
Name and origin of the protein
Protein name Coproporphyrinogen 3 oxidase, aerobic
Synonyms EC 1.3.3.3
Coproporphyrinogen III oxidase, aerobic
Coproporphyrinogenase
Coprogen oxidase
Gene name
Name: hemF
OrderedLocusNames: b2436, JW2429
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=8300522 [NCBI, ExPASy, EBI, Israel, Japan]
Troup B., Jahn M., Hungerer C., Jahn D.;
"Isolation of the hemF operon containing the gene for the Escherichia coli aerobic coproporphyrinogen III oxidase by in vivo complementation of a yeast HEM13 mutant.";
J. Bacteriol. 176:673-680(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/dnares/4.2.91; PubMed=9205837 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.";
DNA Res. 4:91-113(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
CHARACTERIZATION, AND CRYSTALLIZATION.
DOI=10.1016/S0378-1097(03)00531-7; PubMed=13129604 [NCBI, ExPASy, EBI, Israel, Japan]
Breckau D., Mahlitz E., Sauerwald A., Layer G., Jahn D.;
"Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation.";
FEMS Microbiol. Lett. 226:31-37(2003).
[6]
CHARACTERIZATION, AND MUTAGENESIS OF TRP-36; HIS-96; HIS-106; TRP-123; TYR-135; HIS-145; TYR-160; TRP-166; CYS-167; TYR-170; HIS-175; TYR-213; TYR-240; TYR-276 AND TRP-298.
DOI=10.1074/jbc.M308553200; PubMed=12975365 [NCBI, ExPASy, EBI, Israel, Japan]
Breckau D., Mahlitz E., Sauerwald A., Layer G., Jahn D.;
"Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese.";
J. Biol. Chem. 278:46625-46631(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X75413; CAA53167.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC75489.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAA16319.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B36964; B36964.
RefSeq AP_003030.1; -.
NP_416931.1; -.
3D structure databases
ModBase P36553.
Protein-protein interaction databases
IntAct P36553; -.
Enzyme and pathway databases
BioCyc EcoCyc:COPROGENOXI-MON; -.
MetaCyc:COPROGENOXI-MON; -.
Organism-specific databases
EchoBASE EB2106; -.
EcoGene EG12189; hemF.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
HAMAP MF_00333; -; 1.
PBIL [Tree]
InterPro IPR001260; Coprogen_oxidas.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
PANTHER PTHR10755; Coprogen_oxidas; 1.
Pfam PF01218; Coprogen_oxidas; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000166; Coproporphyri_ox; 1.
PRINTS PR00073; COPRGNOXDASE.
PROSITE PS01021; COPROGEN_OXIDASE; 1.
BLOCKS P36553.
Genome annotation databases
GeneID 946908; -.
GenomeReviews U00096_GR; b2436.
AP009048_GR; JW2429.
KEGG ecj:JW2429; -.
eco:b2436; -.
Phylogenomic databases
HOGENOM P36553; -.
Other
LinkHub P36553; -.
Genome annotation databases
CMR P36553; b2436.
Other
ProtoNet P36553.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Manganese; Metal-binding; Oxidoreductase; Porphyrin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   299  299     Coproporphyrinogen 3 oxidase, aerobic. PRO_0000109894
METAL   96    96        Manganese. 
METAL   106   106        Manganese. 
METAL   145   145        Manganese. 
METAL   175   175        Manganese. 
Sequence information
Length: 299 AA [This is the length of the unprocessed precursor] Molecular weight: 34323 Da [This is the MW of the unprocessed precursor] CRC64: 53667E5C7B6D0198 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKPDAHQVKQ FLLNLQDTIC QQLTAVDGAE FVEDSWQREA GGGGRSRVLR NGGVFEQAGV 

        70         80         90        100        110        120 
NFSHVHGEAM PASATAHRPE LAGRSFEAMG VSLVVHPHNP YVPTSHANVR FFIAEKPGAD 

       130        140        150        160        170        180 
PVWWFGGGFD LTPFYGFEED AIHWHRTARD LCLPFGEDVY PRYKKWCDEY FYLKHRNEQR 

       190        200        210        220        230        240 
GIGGLFFDDL NTPDFDRCFA FMQAVGKGYT DAYLPIVERR KAMAYGERER NFQLYRRGRY 

       250        260        270        280        290 
VEFNLVWDRG TLFGLQTGGR TESILMSMPP LVRWEYDYQP KDGSPEAALS EFIKVRDWV 

P36553 in FASTA format

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View entry in raw text format (no links)
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