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UniProtKB/Swiss-Prot entry P36923

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AROD_ENTFA
Primary accession number P36923
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 66)
Name and origin of the protein
Protein name 3-dehydroquinate dehydratase
Synonyms 3-dehydroquinase
EC 4.2.1.10
Type I DHQase
Gene name
Name: aroD
Synonyms: ebsD
OrderedLocusNames: EF_1731
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=OG1SSP;
PubMed=8226689 [NCBI, ExPASy, EBI, Israel, Japan]
Bensing B.A., Dunny G.M.;
"Cloning and molecular analysis of genes affecting expression of binding substance, the recipient-encoded receptor(s) mediating mating aggregate formation in Enterococcus faecalis.";
J. Bacteriol. 175:7421-7429(1993).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L23802; AAC36854.1; -; Unassigned_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE016830; AAO81505.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D49939; D49939.
RefSeq NP_815435.1; -.
3D structure databases
HSSP P24670; 1L9W. [HSSP ENTRY / PDB]
ModBase P36923.
Enzyme and pathway databases
BioCyc EFAE226185:EF_1731-MON; -.
Ontologies
GO
GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00214; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR001381; DHquinase_I.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01487; DHquinase_I; 1.
Pfam graphical view of domain structure.
ProDom PD005337; DHquinase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01093; aroD; 1.
PROSITE PS01028; DEHYDROQUINASE_I; 1.
ProtoNet P36923.
Genome annotation databases
GeneID 1200622; -.
GenomeReviews AE016830_GR; EF_1731.
KEGG efa:EF1731; -.
NMPDR fig|226185.1.peg.1620; -.
TIGR EF_1731; -.
Phylogenomic databases
HOGENOM P36923; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Schiff base.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   253  253     3-dehydroquinate dehydratase. PRO_0000138843
ACT_SITE   143   143        Proton acceptor (By similarity). 
ACT_SITE   170   170        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 253 AA [This is the length of the unprocessed precursor] Molecular weight: 28085 Da [This is the MW of the unprocessed precursor] CRC64: F8F1436A80906B02 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPVIVKNVR IGEGNPKIVV PIVAPTAEDI LAEATASQTL DCDLVEWRLD YYENVADFSD 

        70         80         90        100        110        120 
VCNLSQQVME RLGQKPLLLT FRTQKEGGEM AFSEENYFAL YHELVKKGAL DLLDIELFAN 

       130        140        150        160        170        180 
PLAADTLIHE AKKAGIKIVL CNHDFQKTPS QEEIVARLRQ MQMRQADICK IAVMPQDATD 

       190        200        210        220        230        240 
VLTLLSATNE MYTHYASVPI VTMSMGQLGM ISRVTGQLFG SALTFGSAQQ ASAPGQLSVQ 

       250 
VLRNYLKTFE QNK
P36923 in FASTA format

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