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UniProtKB/Swiss-Prot entry P36969


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPX4_HUMAN
Primary accession number P36969
Secondary accession numbers O43381 Q6PJ59 Q9UPK2
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on February 26, 2008 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 88)
Name and origin of the protein
Protein name Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [Precursor]
Synonyms PHGPx
EC 1.11.1.12
GPX-4
Gene name
Name: GPX4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/0378-1119(94)90400-6; PubMed=8039723 [NCBI, ExPASy, EBI, Israel, Japan]
Esworthy R.S., Doan K., Doroshow J.H., Chu F.-F.;
"Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.";
Gene 144:317-318(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/bbrc.1998.9086; PubMed=9705830 [NCBI, ExPASy, EBI, Israel, Japan]
Kelner M.J., Montoya M.A.;
"Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.";
Biochem. Biophys. Res. Commun. 249:53-55(1998).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASN-2.
Rieder M.J., Livingston R.J., Daniels M.R., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, Eye, Lung, Pancreas, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
VARIANT INFERTILITY THR-120, AND VARIANT ASN-2.
DOI=10.1095/biolreprod.102.007500; PubMed=12606444 [NCBI, ExPASy, EBI, Israel, Japan]
Maiorino M., Bosello V., Ursini F., Foresta C., Garolla A., Scapin M., Sztajer H., Flohe L.;
"Genetic variations of gpx-4 and male infertility in humans.";
Biol. Reprod. 68:1134-1141(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X71973; CAA50793.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF060972; AAC32261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY324108; AAP72965.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004151; AAC03239.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC005390; AAC28920.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011836; AAH11836.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC021567; AAH21567.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022071; AAH22071.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032695; AAH32695.3; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039849; AAH39849.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T02747; T02747.
RefSeq NP_001034936.1; -.
NP_001034937.1; -.
NP_002076.2; -.
UniGene Hs.433951
3D structure databases
PDB
2GS3; X-ray; 1.90 A; A=36-197.[ExPASy / RCSB / EBI]
2OBI; X-ray; 1.55 A; A=29-197.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2GS3; -.
2OBI; -.
ModBase P36969.
Protein family/group databases
PeroxiBase 3603; HsGPx04-a.
3632; HsGPx04-b.
3633; HsGPx04-c.
Enzyme and pathway databases
BioCyc MetaCyc:MON-9881; -.
Polymorphism databases
NIEHS-SNPs GPX4.
2D gel databases
REPRODUCTION-2DPAGE IPI00304814; -.
Organism-specific databases
HGNC HGNC:4556; GPX4.
GenAtlas GPX4.
HPA CAB008630; -.
MIM 138322; gene. [NCBI / EBI]
PharmGKB PA28952; -.
GeneCards P36969.
Gene expression databases
CleanEx HS_GPX4; -.
GermOnline ENSG00000167468; Homo sapiens.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (traceable author statement from UniProtKB).
GO:0004602; Molecular function: glutathione peroxidase activity (traceable author statement from UniProtKB).
GO:0055114; Biological process: oxidation reduction (traceable author statement from UniProtKB).
GO:0006644; Biological process: phospholipid metabolic process (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR11592; Glut_peroxidase; 1.
Pfam PF00255; GSHPx; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000303; Glutathion_perox; 1.
PROSITE PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P36969.
Genome annotation databases
Ensembl ENSG00000167468; Homo sapiens. [Contig view]
GeneID 2879; -.
KEGG hsa:2879; -.
Phylogenomic databases
HOGENOM P36969; -.
HOVERGEN P36969; -.
Other
DrugBank DB00143; Glutathione.
SOURCE GPX4; Homo sapiens.
ProtoNet P36969.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative initiation; Cytoplasm; Developmental protein; Disease mutation; Mitochondrion; Oxidoreductase; Peroxidase; Polymorphism; Selenium; Selenocysteine; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   197        Phospholipid hydroperoxide glutathione peroxidase, mitochondrial. PRO_0000013067
ACT_SITE   73    73         
NON_STD   73    73        Selenocysteine. 
VAR_SEQ   1    27        Missing (in isoform Cytoplasmic). VSP_018740
VARIANT   2     2  1     S -> N. VAR_017063 
VARIANT   120   120  1     A -> T (in infertility; reduced activity). VAR_017064 [3D]
Sequence information
Length: 197 AA [This is the length of the unprocessed precursor] Molecular weight: 22175 Da [This is the MW of the unprocessed precursor] CRC64: 1AE3BC7AE42FDDB1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR 

        70         80         90        100        110        120 
GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA 

       130        140        150        160        170        180 
AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY 

       190 
GPMEEPLVIE KDLPHYF 

P36969 in FASTA format

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