[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1093/nar/22.13.2576; PubMed=8041620 [NCBI, ExPASy, EBI, Israel, Japan] Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.; "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."; Nucleic Acids Res. 22:2576-2586(1994).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan] Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.; "The complete genome sequence of Escherichia coli K-12."; Science 277:1453-1474(1997).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan] Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."; Mol. Syst. Biol. 2:E1-E5(2006).

Comments

CATALYTIC ACTIVITY: 2 ferrocytochrome c + H₂O₂ = 2 ferricytochrome c + 2 H₂O.
PTM: Binds 3 heme groups per subunit (Potential).

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U00039; AAB18494.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC76543.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE77776.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S47738; S47738.

RefSeq

AP_004275.1; -.
NP_417975.1; -.

3D structure databases

HSSP

P14532; 1EB7. [HSSP ENTRY / PDB]

ModBase

P37197.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12244-MON; -.

Organism-specific databases

EchoBASE

EB2155; -.

EcoGene

EG12244; yhjA.

Ontologies

GO:0004130;	Molecular function: cytochrome-c peroxidase activity (inferred from electronic annotation from EC).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037;	Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR009056; Cyt_c_monohaem.
IPR004852; CytCP_MauG.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.760.10; Cytochrome_c_R; 1.

Pfam

PF03150; CCP_MauG; 1.
Pfam graphical view of domain structure.

PROSITE

PS51007; CYTC; 3.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P37197.

Genome annotation databases

GeneID

948038; -.

GenomeReviews

U00096_GR; b3518.
AP009048_GR; JW3486.

KEGG

ecj:JW3486; -.
eco:b3518; -.

Phylogenomic databases

HOGENOM

P37197; -.

Genome annotation databases

CMR

P37197; b3518.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Electron transport; Heme; Iron; Metal-binding; Oxidoreductase; Peroxidase; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 465`	`465`	`Probable cytochrome c peroxidase.`	`PRO_0000108444`
`METAL`	`63 63`		`Iron (heme 1 axial ligand) (By similarity).`
`METAL`	`195 195`		`Iron (heme 1 axial ligand) (By similarity).`
`METAL`	`211 211`		`Iron (heme 2 axial ligand) (By similarity).`
`METAL`	`355 355`		`Iron (heme 3 axial ligand) (By similarity).`
`METAL`	`415 415`		`Iron (heme 2 axial ligand) (By similarity).`
`METAL`	`429 429`		`Iron (heme 3 axial ligand) (By similarity).`
`BINDING`	`59 59`		`Heme 1 (covalent) (By similarity).`
`BINDING`	`62 62`		`Heme 1 (covalent) (By similarity).`
`BINDING`	`207 207`		`Heme 2 (covalent) (By similarity).`
`BINDING`	`210 210`		`Heme 2 (covalent) (By similarity).`
`BINDING`	`351 351`		`Heme 3 (covalent) (By similarity).`
`BINDING`	`354 354`		`Heme 3 (covalent) (By similarity).`

Sequence information

Length: 465 AA [This is the length of the unprocessed precursor]

Molecular weight: 51571 Da [This is the MW of the unprocessed precursor]

CRC64: 9F494A698949E6DA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKMVSRITAI GLAGVAICYL GLSGYVWYHD NKRSKQADVQ ASAVSENNKV LGFLREKGCD 

        70         80         90        100        110        120 
YCHTPSAELP AYYYIPGAKQ LMDYDIKLGY KSFNLEAVRA ALLADKPVSQ SDLNKIEWVM 

       130        140        150        160        170        180 
QYETMPPTRY TALHWAGKVS DEERAEILAW IAKQRAEYYA SNDTAPEHRN EPVQPIPQKL 

       190        200        210        220        230        240 
PTDAQKVALG FALYHDPRLS ADSTISCAHC HALNAGGVDG RKTSIGVGGA VGPINAPTVF 

       250        260        270        280        290        300 
NSVFNVEQFW DGRAATLQDQ AGGPPLNPIE MASKSWDEII AKLEKDPQLK TQFLEVYPQG 

       310        320        330        340        350        360 
FSGENITDAI AEFEKTLITP DSPFDKWLRG DENALTAQQK KGYQLFKDNK CATCHGGIIL 

       370        380        390        400        410        420 
GGRSFEPLGL KKDFNFGEIT AADIGRMNVT KEERDKLRQK VPGLRNVALT APYFHRGDVP 

       430        440        450        460 
TLDGAVKLML RYQVGKELPQ EDVDDIVAFL HSLNGVYTPY MQDKQ

P37197 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools