[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1093/nar/22.13.2576; PubMed=8041620 [NCBI, ExPASy, EBI, Israel, Japan] Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.; "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."; Nucleic Acids Res. 22:2576-2586(1994).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan] Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.; "The complete genome sequence of Escherichia coli K-12."; Science 277:1453-1474(1997).
[3]	SEQUENCE REVISION TO 380-383. DOI=10.1093/nar/gkj405; PubMed=16397293 [NCBI, ExPASy, EBI, Israel, Japan] Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L.; "Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005."; Nucleic Acids Res. 34:1-9(2006).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan] Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."; Mol. Syst. Biol. 2:E1-E5(2006).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-383. STRAIN=K12 / MG1655 / ATCC 47076; PubMed=7768815 [NCBI, ExPASy, EBI, Israel, Japan] Xu J., Johnson R.C.; "aldB, an RpoS-dependent gene in Escherichia coli encoding an aldehyde dehydrogenase that is repressed by Fis and activated by Crp."; J. Bacteriol. 177:3166-3175(1995).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Iron (By similarity).
SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U00039; AAB18566.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAT48195.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE77704.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L40742; AAC36938.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S47810; S47810.

RefSeq

AP_004203.1; -.
YP_026233.1; -.

3D structure databases

ModBase

P37686.

Protein-protein interaction databases

DIP

DIP:12414N; -.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12293-MON; -.

Organism-specific databases

EchoBASE

EB2201; -.

EcoGene

EG12293; yiaY.

Ontologies

GO:0004022;	Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001670; Fe_AlcDHase.
Graphical view of domain structure.

Pfam

PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.

PROSITE

PS00913; ADH_IRON_1; 1.
PS00060; ADH_IRON_2; 1.

ProtoNet

P37686.

Genome annotation databases

GeneID

948102; -.

GenomeReviews

U00096_GR; b3589.
AP009048_GR; JW5648.

KEGG

ecj:JW5648; -.
eco:b3589; -.

Phylogenomic databases

HOGENOM

P37686; -.

Genome annotation databases

CMR

P37686; b3589.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Iron; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 383`	`383`	`Probable alcohol dehydrogenase.`	`PRO_0000087816`
`CONFLICT`	`380 383`		`RAAM -> AAR (in Ref. 1; AAB18566).`

Sequence information

Length: 383 AA [This is the length of the unprocessed precursor]

Molecular weight: 40351 Da [This is the MW of the unprocessed precursor]

CRC64: 805DC4E488E108F6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAASTFFIPS VNVIGADSLT DAMNMMADYG FTRTLIVTDN MLTKLGMAGD VQKALEERNI 

        70         80         90        100        110        120 
FSVIYDGTQP NPTTENVAAG LKLLKENNCD SVISLGGGSP HDCAKGIALV AANGGDIRDY 

       130        140        150        160        170        180 
EGVDRSAKPQ LPMIAINTTA GTASEMTRFC IITDEARHIK MAIVDKHVTP LLSVNDSSLM 

       190        200        210        220        230        240 
IGMPKSLTAA TGMDALTHAI EAYVSIAATP ITDACALKAV TMIAENLPLA VEDGSNAKAR 

       250        260        270        280        290        300 
EAMAYAQFLA GMAFNNASLG YVHAMAHQLG GFYNLPHGVC NAVLLPHVQV FNSKVAAARL 

       310        320        330        340        350        360 
RDCAAAMGVN VTGKNDAEGA EACINAIREL AKKVDIPAGL RDLNVKEEDF AVLATNALKD 

       370        380 
ACGFTNPIQA THEEIVAIYR AAM

P37686 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools