NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8550525 [NCBI, ExPASy, EBI, Israel, Japan]
Soehling B., Gottschalk G.;
"Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri.";
J. Bacteriol. 178:871-880(1996).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0711093105; PubMed=18218779 [NCBI, ExPASy, EBI, Israel, Japan]
Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.;
"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features.";
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).

Comments

CATALYTIC ACTIVITY: 4-hydroxybutanoate + NAD⁺ = succinate semialdehyde + NADH.
COFACTOR: Divalent cations.
SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L21902; AAA92348.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000673; EDK35022.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001396393.1; -.

3D structure databases

ModBase

P38945.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-13466; -.

Ontologies

GO:0047577;	Molecular function: 4-hydroxybutyrate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0046872;	Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001670; Fe_AlcDHase.
Graphical view of domain structure.

Pfam

PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.

PROSITE

PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; 1.

ProtoNet

P38945.

Genome annotation databases

GeneID

5394465; -.

GenomeReviews

CP000673_GR; CKL_3014.

KEGG

ckl:CKL_3014; -.

CMR

P38945; CKL_3014.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 371`	`371`		`NAD-dependent 4-hydroxybutyrate dehydrogenase.`	`PRO_0000087840`

Sequence information

Length: 371 AA [This is the length of the unprocessed precursor]

Molecular weight: 41756 Da [This is the MW of the unprocessed precursor]

CRC64: 8D4A8DCD94E252C4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKLLKLAPDV YKFDTAEEFM KYFKVGKGDF ILTNEFLYKP FLEKFNDGAD AVFQEKYGLG 

        70         80         90        100        110        120 
EPSDEMINNI IKDIGDKQYN RIIAVGGGSV IDIAKILSLK YTDDSLDLFE GKVPLVKNKE 

       130        140        150        160        170        180 
LIIVPTTCGT GSEVTNVSVA ELKRRHTKKG IASDELYATY AVLVPEFIKG LPYKFFVTSS 

       190        200        210        220        230        240 
VDALIHATEA YVSPNANPYT DMFSVKAMEL ILNGYMQMVE KGNDYRVEII EDFVIGSNYA 

       250        260        270        280        290        300 
GIAFGNAGVG AVHALSYPIG GNYHVPHGEA NYLFFTEIFK TYYEKNPNGK IKDVNKLLAG 

       310        320        330        340        350        360 
ILKCDESEAY DSLSQLLDKL LSRKPLREYG MKEEEIETFA DSVIEGQQRL LVNNYEPFSR 

       370 
EDIVNTYKKL Y

P38945 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools