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UniProtKB/Swiss-Prot entry P39051

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYTR_TRYBB
Primary accession number P39051
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Trypanothione reductase
Synonyms TR
EC 1.8.1.12
N(1),N(8)-bis(glutathionyl)spermidine reductase
Gene name
Name: TPR
From
Trypanosoma brucei brucei [TaxID: 5702] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ILTAT 1.1;
PubMed=1453951 [NCBI, ExPASy, EBI, Israel, Japan]
Aboagye-Kwarteng T., Smith K., Fairlamb A.H.;
"Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism.";
Mol. Microbiol. 6:3089-3099(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X63188; CAA44870.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S28003; S28003.
3D structure databases
HSSP P28593; 1NDA. [HSSP ENTRY / PDB]
SMR P39051; 2-485.
ModBase P39051.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0015036; Molecular function: disulfide oxidoreductase activity (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0015042; Molecular function: trypanothione-disulfide reductase activity (inferred from electronic annotation from EC).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR001864; Trypnth_redctse.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
PR00470; TRYPANRDTASE.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01423; trypano_reduc; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
ProtoNet P39051.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   492  492     Trypanothione reductase. PRO_0000067990
NP_BIND   35    52  18     FAD (By similarity). 
ACT_SITE   461   461        Proton acceptor (By similarity). 
DISULFID   52    57        Redox-active (By similarity). 
Sequence information
Length: 492 AA [This is the length of the unprocessed precursor] Molecular weight: 53284 Da [This is the MW of the unprocessed precursor] CRC64: FFCA2F11B66F7FF4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKIFDLVVI GAGSGGLEAG WNAATLYKKR VAVIDVQTHH GPPHYAALGG TCVNVGCVPK 

        70         80         90        100        110        120 
KLMVTGAQYM DHLRESAGFG WEFDGSSVKA NWKKLIAAKN EAVLDINKSY EGMFNDTEGL 

       130        140        150        160        170        180 
DFFLGWGSLE SKNVVVVRET ADPKSAVKER LQADHILLAT GSWPQMPAIP GVEHCISSNE 

       190        200        210        220        230        240 
AFYLPEPPRR VLTVGGGFIS VEFAGIFNAY KPPGGKVTLC YRNNLILRGF DETIREEVTK 

       250        260        270        280        290        300 
QLTANGIEIM TNENPAKVSL NTDGSKHVTF ESGKTLDVDV VMMAIGRIPR TNDLQLGNVG 

       310        320        330        340        350        360 
VKLTPKGGVQ VDEFSRTNVP NIYAIGDITD RLMLTPVAIN EGAALVDTVF GNKPRKTDHT 

       370        380        390        400        410        420 
RVASAVFSIP PIGTCGLIEE VAAKEFEKVA VYMSSFTPLM HNISGSKYKK FVAKIVTNHS 

       430        440        450        460        470        480 
DGTVLGVHLL GDGAPEIIQA VGVCLRLNAK ISDFYNTIGV HPTSAEELCS MRTPSYYYLK 

       490 
GEKMETLPES SL
P39051 in FASTA format

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