NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(94)90725-0; PubMed=8125334 [NCBI, ExPASy, EBI, Israel, Japan]
Benachenhou-Lahfa N., Labedan B., Forterre P.;
"PCR-mediated cloning and sequencing of the gene encoding glutamate dehydrogenase from the archaeon Sulfolobus shibatae: identification of putative amino-acid signatures for extremophilic adaptation.";
Gene 140:17-24(1994).

Comments

CATALYTIC ACTIVITY: L-glutamate + H₂O + NADP⁺ = 2-oxoglutarate + NH₃ + NADPH.
SUBUNIT: Homohexamer.
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X73990; CAA52168.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S37407; S37407.

3D structure databases

HSSP

P96110; 2TMG. [HSSP ENTRY / PDB]

ModBase

P39475.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11606:SF2; GLFV_DH; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000185; Glu_DH; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 390`	`>390`	`NADP-specific glutamate dehydrogenase.`	`PRO_0000182781`
`ACT_SITE`	`81 81`		`By similarity.`
`NON_TER`	`1 1`

Sequence information

Length: 390 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 42091 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: BCB9ACFE6AC9CEB2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
LDTLEALSQP ERVIQVKIQI RGSDGKLKTF MGWRSQHNSA LGPYKGGVRY SPNVTQDEVI 

        70         80         90        100        110        120 
ALSMIMTWKN SLLLLPYGGG KGGIRVDPKK LTLKELEDLS RKYVQLIHNY LGSDVDIPAP 

       130        140        150        160        170        180 
DINTNPQTMA WFLDEYIKIT GEVDFAVFTG KPSELGGIGV RLYSTGLGVA TIAREAANKF 

       190        200        210        220        230        240 
IGGIEGSRVI IQGFGNVGSF TAKFLNEMGA KIIGVSDIGG GVISDDGIDV NKALEVVQST 

       250        260        270        280        290        300 
GSVVNYPEGK KVTNEELLTS DCDILIPAAV ENVINKFNAP KVKAKLIVEG ANGPLAADAD 

       310        320        330        340        350        360 
EIIKQRGIVV IPDILANAGG VVGSYVEWAN NKSGGIISDE EAKKLIIDRM TNAFNALYEF 

       370        380        390 
HKRKFADQDL RTVAMALRVD RVVGMKARAI

P39475 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools