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UniProtKB/Swiss-Prot entry P39708

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE5_YEAST
Primary accession number P39708
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name NADP-specific glutamate dehydrogenase 2
Synonyms NADP-GDH 2
EC 1.4.1.4
NADP-dependent glutamate dehydrogenase 2
Gene name
Name: GDH3
OrderedLocusNames: YAL062W
ORFNames: FUN51
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=7731988 [NCBI, ExPASy, EBI, Israel, Japan]
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.;
"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U12980; AAC04972.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S51960; S51960.
RefSeq NP_009339.1; -.
3D structure databases
HSSP P24295; 1AUP. [HSSP ENTRY / PDB]
ModBase P39708.
Protein-protein interaction databases
DIP DIP:4325N; -.
IntAct P39708; -.
Enzyme and pathway databases
BioCyc MetaCyc:MON-11505; -.
Organism-specific databases
CYGD YAL062w; -.
SGD S000000058; GDH3.
Yeast-GFP YAL062W.
Gene expression databases
ArrayExpress P39708; -.
GermOnline YAL062W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from SGD).
GO:0005634; Cellular component: nucleus (inferred from direct assay from SGD).
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from SGD).
GO:0004352; Molecular function: glutamate dehydrogenase activity (inferred from mutant phenotype from SGD).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006537; Biological process: glutamate biosynthetic process (inferred from genetic interaction from SGD).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS P39708.
Proteomic databases
PeptideAtlas P39708; -.
Genome annotation databases
Ensembl YAL062W; Saccharomyces cerevisiae. [Contig view]
GeneID 851237; -.
GenomeReviews U00091_GR; YAL062W.
KEGG sce:YAL062W; -.
NMPDR fig|4932.3.peg.13; -.
Phylogenomic databases
HOGENOM P39708; -.
Other
LinkHub P39708; -.
ProtoNet P39708.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   457  457     NADP-specific glutamate dehydrogenase 2. PRO_0000182799
NP_BIND   175   204  30     NAD (By similarity). 
ACT_SITE   111   111        By similarity. 
Sequence information
Length: 457 AA [This is the length of the unprocessed precursor] Molecular weight: 49627 Da [This is the MW of the unprocessed precursor] CRC64: 81B30625038B1888 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW ENDNGEQEVA 

        70         80         90        100        110        120 
QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN ALTGLDMGGG KGGLCVDLKG 

       130        140        150        160        170        180 
KSDNEIRRIC YAFMRELSRH IGKDTDVPAG DIGVGGREIG YLFGAYRSYK NSWEGVLTGK 

       190        200        210        220        230        240 
GLNWGGSLIR PEATGFGLVY YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL 

       250        260        270        280        290        300 
GGIVVSLSDS KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR 

       310        320        330        340        350        360 
PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS VFETARSTAT 

       370        380        390        400        410        420 
NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV DQELKKIMIN CFNDCIQAAQ 

       430        440        450 
EYSTEKNTNT LPSLVKGANI ASFVMVADAM LDQGDVF
P39708 in FASTA format

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