[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169868 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S.,
Mulligan J.T.,
Hennessy K.M.,
Yelton M.A.,
Allen E.,
Araujo R.,
Aviles E.,
Berno A.,
Brennan T.,
Carpenter J.,
Chen E.,
Cherry J.M.,
Chung E.,
Duncan M.,
Guzman E.,
Hartzell G.,
Hunicke-Smith S.,
Hyman R.W.,
Kayser A., ![]()
Komp C.,
Lashkari D.,
Lew H.,
Lin D.,
Mosedale D.,
Nakahara K.,
Namath A.,
Norgren R.,
Oefner P.,
Oh C.,
Petel F.X.,
Roberts D.,
Sehl P.,
Schramm S.,
Shogren T.,
Smith V.,
Taylor P.,
Wei Y.,
Botstein D.,
Davis R.W.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
Nature 387:78-81(1997).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y.,
Rolfs A.,
Bhullar B.,
Murthy T.V.S.,
Zhu C.,
Berger M.F.,
Camargo A.A.,
Kelley F.,
McCarron S.,
Jepson D.,
Richardson A.,
Raphael J.,
Moreira D.,
Taycher E.,
Zuo D.,
Mohr S.,
Kane M.F.,
Williamson J.,
Simpson A.J.G., ![]()
Bulyk M.L.,
Harlow E.,
Marsischky G.,
Kolodner R.D.,
LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
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[3]
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FUNCTION.
PubMed=11160377 [NCBI, ExPASy, EBI, Israel, Japan]
Gachotte D.,
Eckstein J.,
Barbuch R.,
Hughes T.,
Roberts C.,
Bard M.;
"A novel gene conserved from yeast to humans is involved in sterol biosynthesis.";
J. Lipid Res. 42:150-154(2001).
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[4]
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SUBUNIT, INTERACTION WITH ERG25 AND ERG27, AND SUBCELLULAR LOCATION.
DOI=10.1073/pnas.112202799; PubMed=12119386 [NCBI, ExPASy, EBI, Israel, Japan]
Mo C.,
Valachovic M.,
Randall S.K.,
Nickels J.T.,
Bard M.;
"Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis.";
Proc. Natl. Acad. Sci. U.S.A. 99:9739-9744(2002).
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[5]
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LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S.,
Huh W.-K.,
Bower K.,
Howson R.W.,
Belle A.,
Dephoure N.,
O'Shea E.K.,
Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
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[6]
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INTERACTION WITH ERG6.
DOI=10.1016/j.bbalip.2004.08.001; PubMed=15522820 [NCBI, ExPASy, EBI, Israel, Japan]
Mo C.,
Valachovic M.,
Bard M.;
"The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p).";
Biochim. Biophys. Acta 1686:30-36(2004).
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[7]
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INTERACTION WITH ERG1; ERG3; ERG5; ERG6; ERG11; ERG25; ERG26 AND ERG27.
DOI=10.1194/jlr.M500153-JLR200; PubMed=15995173 [NCBI, ExPASy, EBI, Israel, Japan]
Mo C.,
Bard M.;
"Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex.";
J. Lipid Res. 46:1991-1998(2005).
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[8]
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TOPOLOGY [LARGE SCALE ANALYSIS].
DOI=10.1073/pnas.0604075103; PubMed=16847258 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H.,
Melen K.,
Oesterberg M.,
von Heijne G.;
"A global topology map of the Saccharomyces cerevisiae membrane proteome.";
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
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- FUNCTION: Has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction.
- SUBUNIT: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25, ERG26 and ERG27. Also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11.
- INTERACTION:
P53045:ERG25; NbExp=1; IntAct=EBI-22518, EBI-6506;
P53199:ERG26; NbExp=1; IntAct=EBI-22518, EBI-6514;
Q12452:ERG27; NbExp=2; IntAct=EBI-22518, EBI-38132;
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable).
- MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.
- SIMILARITY: Belongs to the ERG28 family.
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