ID   ALDH_CLAHE              Reviewed;         496 AA.
AC   P40108;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   04-NOV-2008, entry version 52.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            Short=ALDDH;
DE            Short=ALDH;
DE            EC=1.2.1.3;
DE   AltName: Full=Allergen Cla h 3;
DE   AltName: Full=Allergen Cla h III;
DE   AltName: Allergen=Cla h 10;
GN   Name=CLAH10; Synonyms=CLAH3;
OS   Cladosporium herbarum (Davidiella tassiana).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Dothideomycetidae; Capnodiales; Davidiellaceae;
OC   Davidiella.
OX   NCBI_TaxID=29918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGENICITY.
RC   STRAIN=280202-Berlin;
RX   MEDLINE=95206305; PubMed=7898496; DOI=10.1016/0161-5890(94)00108-D;
RA   Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A.,
RA   Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.;
RT   "Molecular cloning of major and minor allergens of Alternaria
RT   alternata and Cladosporium herbarum.";
RL   Mol. Immunol. 32:213-227(1995).
RN   [2]
RP   SEQUENCE REVISION TO 66; 74; 95; 110; 114-121; 158-165 AND 367.
RA   Simon-Nobbe B.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; X78228; CAA55072.2; -; mRNA.
DR   PIR; S43114; S43114.
DR   HSSP; P05091; 1O04.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN         1    496       Aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056437.
FT   ACT_SITE    263    263       By similarity.
FT   ACT_SITE    296    296       By similarity.
SQ   SEQUENCE   496 AA;  53554 MW;  D938B5D0D9B26999 CRC64;
     MTSVQLETPH SGKYEQPTGL FINNEFVKGQ EGKTFDVINP SDESVITQVH EATEKDVDIA
     VAAARKAFEG SWRQETPENR GKLLNNLANL FEKNIDLLAA VESLDNGKAI SMAKGDISMC
     VGCLRYYGGW ADKITGKVID TTPDTFNYVK KEPIGVCGQI IPWNFPLLMW AWKIGPAIAC
     GNTVVLKTAE QTPLGGLVAA SLVKEAGFPP GVINVISGFG KVAGAALSSH MDVDKVAFTG
     STVVGRTILK AAASSNLKKV TLELGGKSPN IVFEDADIDN AISWVNFGIF FNHGQCCCAG
     SRVYVQESIY DKFVQKFKER AQKNVVGDPF AADTFQGPQV SKVQFDRIME YIQAGKDAGA
     TVETGGKRKG DKGYFIEPTI FSNVTEDMKI VKEEIFGPVC SIAKFKTKED AIKLGNASTY
     GLAAAVHTKN LNTAIEVSNA LKAGTVWVNT YNTLHHQMPF GGYKESGIGR ELGEDALANY
     TQTKTVSIRL GDALFG
//