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UniProtKB/Swiss-Prot entry P40952


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KYE1_KLULA
Primary accession number P40952
Secondary accession number Q6CXE2
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on September 27, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name NADPH dehydrogenase 1
Synonyms EC 1.6.99.1
Old yellow enzyme 1
Gene name
Name: KYE1
OrderedLocusNames: KLLA0A09075g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
PubMed=7597850 [NCBI, ExPASy, EBI, Israel, Japan]
Miranda M., Ramirez J., Guevara S., Ongay-Larios L., Pena A., Coria R.;
"Nucleotide sequence and chromosomal localization of the gene encoding the Old Yellow Enzyme from Kluyveromyces lactis.";
Yeast 11:459-465(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L37452; AAA98815.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR382121; CAH02985.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S55844; S55844.
RefSeq XP_451397.1; -.
3D structure databases
HSSP Q02899; 1OYC. [HSSP ENTRY / PDB]
SMR P40952; 5-398.
ModBase P40952.
Ontologies
GO
GO:0003959; Molecular function: NADPH dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR001155; OxRdtase_FMN_N.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00724; Oxidored_FMN; 1.
Pfam graphical view of domain structure.
BLOCKS P40952.
Genome annotation databases
GeneID 2896828; -.
KEGG kla:KLLA0A09075g; -.
Phylogenomic databases
HOGENOM P40952; -.
Other
ProtoNet P40952.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Flavoprotein; FMN; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   398  398     NADPH dehydrogenase 1. PRO_0000194476
ACT_SITE   196   196        Proton donor (By similarity). 
BINDING   37    37        FMN (By similarity). 
BINDING   191   191        FMN (By similarity). 
BINDING   191   191        Substrate (By similarity). 
BINDING   194   194        Substrate (By similarity). 
BINDING   243   243        FMN (By similarity). 
BINDING   348   348        FMN (By similarity). 
BINDING   375   375        Substrate (By similarity). 
CONFLICT   256   256        G -> V (in Ref. 1; AAA98815). 
Sequence information
Length: 398 AA [This is the length of the unprocessed precursor] Molecular weight: 44780 Da [This is the MW of the unprocessed precursor] CRC64: AA40CCC0C2BE6EC1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSFMNFEPKP LADTDIFKPI KIGNTELKHR VVMPALTRMR ALHPGNVPNP DWAVEYYRQR 

        70         80         90        100        110        120 
SQYPGTMIIT EGAFPSAQSG GYDNAPGVWS EEQLAQWRKI FKAIHDNKSF VWVQLWVLGR 

       130        140        150        160        170        180 
QAFADNLARD GLRYDSASDE VYMGEDEKER AIRSNNPQHG ITKDEIKQYI RDYVDAAKKC 

       190        200        210        220        230        240 
IDAGADGVEI HSANGYLLNQ FLDPISNKRT DEYGGSIENR ARFVLEVVDA VVDAVGAERT 

       250        260        270        280        290        300 
SIRFSPYGVF GTMSGGSDPV LVAQFAYVLA ELEKRAKAGK RLAYVDLVEP RVTSPFQPEF 

       310        320        330        340        350        360 
EGWYKGGTNE FVYSVWKGNV LRVGNYALDP DAAITDSKNP NTLIGYGRAF IANPDLVERL 

       370        380        390 
EKGLPLNQYD RPSFYKMSAE GYIDYPTYEE AVAKGYKK 

P40952 in FASTA format

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