ID   PNTAA_RICPR             Reviewed;         383 AA.
AC   P41077;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-NOV-2008, entry version 55.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha part 1;
DE            EC=1.6.1.2;
DE   AltName: Full=Nicotinamide nucleotide transhydrogenase subunit alpha 1;
DE   AltName: Full=Pyridine nucleotide transhydrogenase subunit alpha 1;
GN   Name=pntAA; OrderedLocusNames=RP863;
OS   Rickettsia prowazekii.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=782;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   MEDLINE=99039499; PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA   Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA   Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 215-383.
RC   STRAIN=Madrid E;
RX   MEDLINE=97474271; PubMed=9335295;
RA   Shaw E.I., Marks G.L., Winkler H.H., Wood D.O.;
RT   "Transcriptional characterization of the Rickettsia prowazekii major
RT   macromolecular synthesis operon.";
RL   J. Bacteriol. 179:6448-6452(1997).
RN   [3]
RP   GENE NAME.
RX   MEDLINE=96259307; PubMed=8662004; DOI=10.1007/BF02352282;
RA   Andersson S.G.E., Sharp P.M.;
RT   "Codon usage and base composition in Rickettsia prowazekii.";
RL   J. Mol. Evol. 42:525-536(1996).
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC   -!- SUBUNIT: Complex of an alpha and a beta chain; in Rickettsia, the
CC       alpha chain seems to be made of two subunits.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
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DR   EMBL; AJ235273; CAA15287.1; -; Genomic_DNA.
DR   EMBL; U02878; AAB81400.1; -; Unassigned_DNA.
DR   PIR; G71648; G71648.
DR   RefSeq; NP_221211.1; -.
DR   HSSP; Q60164; 1L7D.
DR   GeneID; 883431; -.
DR   GenomeReviews; AJ235269_GR; RP863.
DR   KEGG; rpr:RP863; -.
DR   HOGENOM; P41077; -.
DR   BioCyc; RPRO272947:RP863-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) acti...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR007698; Ala_DHase/PNT_C.
DR   InterPro; IPR008142; Ala_DHase/PNT_CS1.
DR   InterPro; IPR007886; Ala_DHase/PNT_N.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    383       NAD(P) transhydrogenase subunit alpha
FT                                part 1.
FT                                /FTId=PRO_0000199020.
SQ   SEQUENCE   383 AA;  41638 MW;  70FC641B1F7C35C9 CRC64;
     MKIVALKEKV KNETRTAITP EVAGLLIKKG YAVTVEKDIG LYAGFLDEEY VAVGTKISSV
     PLEIISDADI ILKVQPSSVT DKYSELEFAK QGAIVVGLLS PYLNHEYIKA AAKKNLTTFA
     MEFVPRITKA QNMDALSSQS NLVGYRAVIE ASYHYTKAFP MMITAAGTIS ACKTLVLGVG
     VAGLQAIATA KRLGSIVAGY DVRIATKEQV ESLGAKFVSP ELQEDLEEES GYASESSADY
     KAKQEKFLAK IIKGYNIVIT TAQIPGKKAP MLVTDKMIES MMYGSVIVDI STSTGGNVEG
     SEPDKIVTRH GVTIIGLLNL ASKIASDSSK LYSKNLYNFL TYALQDGQFN MDDELVRDML
     ITKDGKIVNY IIREKYESIT DNG
//