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UniProtKB/Swiss-Prot entry P41564

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3G_MACFA
Primary accession number P41564
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial [Precursor] [Fragment]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
Name: IDH3G
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=8240232 [NCBI, ExPASy, EBI, Israel, Japan]
Nichols B.J., Hall L., Perry A.C.F., Denton R.M.;
"Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases.";
Biochem. J. 295:347-350(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X74124; CAA52224.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S39065; S39065.
3D structure databases
HSSP P00351; 1XAA. [HSSP ENTRY / PDB]
ModBase P41564.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from UniProtKB).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004449; Molecular function: isocitrate dehydrogenase (NAD+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006102; Biological process: isocitrate metabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
ProtoNet P41564.
Phylogenomic databases
HOVERGEN P41564; -.
Other
LinkHub P41564; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   <1     1  >1     Mitochondrion (By similarity). 
CHAIN   2   355  354     Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial. PRO_0000014450
NP_BIND   18    46  29     NAD (Potential). 
NP_BIND   271   278  8     ATP (Potential). 
METAL   216   216        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   216   216        Substrate (By similarity). 
SITE   136   136  1     Critical for catalysis (By similarity). 
SITE   183   183  1     Critical for catalysis (By similarity). 
MOD_RES   325   325        Phosphothreonine (By similarity). 
NON_TER   1     1         
Sequence information
Length: 355 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 38881 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: CC1EEFF0582B6813 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
ISSQQTIPPS AKYGGRHTVT MIPGDGIGPE LMLHVKSVFR HACVPVDFEE VHVSSNADEE 

        70         80         90        100        110        120 
DIRNAIMAIR RNRVALKGNI ETNHNLPPSH KSRNNILRTS LDLYANVIHC KSLPGVVTRH 

       130        140        150        160        170        180 
KDIDILIVRE NTEGEYSSLE HESVAGVVES LKIITKAKSL RIAEYAFKLA QESGRKKVTA 

       190        200        210        220        230        240 
VHKANIMKLG DGLFLQCCRE VAARYPQITF ENMIVDNTTM QLVSRPQQFD VMVMPNLYGN 

       250        260        270        280        290        300 
IVNNVCAGLV GGPGLVAGAN YGHVYAVFET ATRNTGKSIA NKNIANPTAT LLASCMMLDH 

       310        320        330        340        350 
LKLHSYATSI RKAVLASMDN ENMHTPDIGG QGTTSEAIQD IIRHIRVING RAVEA
P41564 in FASTA format

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