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UniProtKB/Swiss-Prot entry P41574

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 6PGD_ESCVU
Primary accession number P41574
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 47)
Name and origin of the protein
Protein name 6-phosphogluconate dehydrogenase, decarboxylating [Fragment]
Synonym EC 1.1.1.44
Gene name
Name: gnd
From
Escherichia vulneris [TaxID: 566] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 33821 / DSM 4564 / JCM 1688 / LMG 7868 / NCTC 12130;
PubMed=7937867 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K., Selander R.K.;
"Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U14465; AAC43815.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00349; 2PGD. [HSSP ENTRY / PDB]
ModBase P41574.
Ontologies
GO
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004616; Molecular function: phosphogluconate dehydrogenase (decarboxylating) activity (inferred from electronic annotation from InterPro).
GO:0019521; Biological process: D-gluconate metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006098; Biological process: pentose-phosphate shunt (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR00873; gnd; 1.
PROSITE PS00461; 6PGD; 1.
ProtoNet P41574.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   <1   >445  >445     6-phosphogluconate dehydrogenase, decarboxylating. PRO_0000090039
NON_TER   1      1         
NON_TER   445    445         
Sequence information
Length: 445 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 48806 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 0315BE126C2A45FE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
AVMGRNLALN IESRGYTVSV FNRSREKTEE VVAENPGKKL VPYYTVQEFV ESLETPRRIL 

        70         80         90        100        110        120 
LMVQAGAGTD AAINSLKPYL DKGDIIIDGG NTFFHDTIRR NRELSAEGFN FIGTGVSGGE 

       130        140        150        160        170        180 
EGALKGPSIM PGGQKEAYEL VAPILTKIAA VAEDGEPCVT YIGADGAGHY VKMVHNGIEY 

       190        200        210        220        230        240 
GDMQLIAEAY SLLKGGLNLS NEELAQTFTE WNKGELSSYL IDITKDIFTK KDEEGKYLVD 

       250        260        270        280        290        300 
VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKEQRVAASK VLSGPQSQPA 

       310        320        330        340        350        360 
GDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASEEYNWDL NYGEIAKIFR AGCIIRAQFL 

       370        380        390        400        410        420 
QKITDAYAET PAIANLLLAP YFKQIADDYQ QALRDVVAYA VQNGIPVPTF GAAVAYYDSY 

       430        440 
RAAVLPANLI QAQRDYFGAH TYKRT
P41574 in FASTA format

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