NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 33531 / DSM 3069 / IFO 14939 / JCM 7251 / V-236;
PubMed=7937867 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K., Selander R.K.;
"Intergeneric transfer and recombination of the 6-phosphogluconate dehydrogenase gene (gnd) in enteric bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994).

Comments

CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 .
SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U14464; AAC43816.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00349; 2PGD. [HSSP ENTRY / PDB]

ModBase

P41575.

Family and domain databases

InterPro

IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR00076; 6PGDHDRGNASE.

TIGR00873; gnd; 1.

PS00461; 6PGD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >445`	`>445`	`6-phosphogluconate dehydrogenase, decarboxylating.`	`PRO_0000090042`
`NON_TER`	`1 1`
`NON_TER`	`445 445`

Sequence information

Length: 445 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 48829 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 48E581E9B9290681 [This is a checksum on the sequence]

        10         20         30         40         50         60 
AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPHYTVKEFV ESLETPRRIL 

        70         80         90        100        110        120 
LMVKAGAGTD SAIDSLKPYL NKGDIIIDGG NTFFQDTIRR NRELSAEGFN FIGTGVSGGE 

       130        140        150        160        170        180 
EGALKGPSIM PGGQKEAYEL VAPILEQIAA RAEDGEPCVA YIGADGAGHY VKMVHNGIEY 

       190        200        210        220        230        240 
GDMQLIAEAY ALLKGGLALS NEELATTFTK WNEGELSSYL IDITKDIFTK KDEEGKYLVD 

       250        260        270        280        290        300 
VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKDQRVAASK VLTGPKAQPA 

       310        320        330        340        350        360 
GDKAEFVEKV RRALYLGKIV SYAQGFSQLR AASNEYNWDL NYGEIAKIFR AGCIIRAQFL 

       370        380        390        400        410        420 
QKITDAYEQN AGIANLLLAP YFKQIADEYQ QALRDVVAYA VQNGIPVPTF SAAIAYYDSY 

       430        440 
RSAVLPANLI QAQRDYFGAH TYKRT

P41575 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools