ID   6PGD_KLEPL              Reviewed;         445 AA.
AC   P41575;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 49.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
DE   Flags: Fragment;
GN   Name=gnd;
OS   Klebsiella planticola (Raoultella planticola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Raoultella.
OX   NCBI_TaxID=575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33531 / DSM 3069 / IFO 14939 / JCM 7251 / V-236;
RX   MEDLINE=95024018; PubMed=7937867;
RA   Nelson K., Selander R.K.;
RT   "Intergeneric transfer and recombination of the 6-phosphogluconate
RT   dehydrogenase gene (gnd) in enteric bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994).
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; U14464; AAC43816.1; -; Genomic_DNA.
DR   HSSP; P00349; 2PGD.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:InterPro.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   InterPro; IPR006183; 6-phosphogluconate_DHase.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
FT   CHAIN        <1   >445       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090042.
FT   NON_TER       1      1
FT   NON_TER     445    445
SQ   SEQUENCE   445 AA;  48829 MW;  48E581E9B9290681 CRC64;
     AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPHYTVKEFV ESLETPRRIL
     LMVKAGAGTD SAIDSLKPYL NKGDIIIDGG NTFFQDTIRR NRELSAEGFN FIGTGVSGGE
     EGALKGPSIM PGGQKEAYEL VAPILEQIAA RAEDGEPCVA YIGADGAGHY VKMVHNGIEY
     GDMQLIAEAY ALLKGGLALS NEELATTFTK WNEGELSSYL IDITKDIFTK KDEEGKYLVD
     VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKDQRVAASK VLTGPKAQPA
     GDKAEFVEKV RRALYLGKIV SYAQGFSQLR AASNEYNWDL NYGEIAKIFR AGCIIRAQFL
     QKITDAYEQN AGIANLLLAP YFKQIADEYQ QALRDVVAYA VQNGIPVPTF SAAIAYYDSY
     RSAVLPANLI QAQRDYFGAH TYKRT
//