ID   6PGD_KLETE              Reviewed;         445 AA.
AC   P41577;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 48.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
DE   Flags: Fragment;
GN   Name=gnd;
OS   Klebsiella terrigena (Raoultella terrigena).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Raoultella.
OX   NCBI_TaxID=577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33257 / DSM 2687 / IFO 14941 / NCTC 13038;
RX   MEDLINE=95024018; PubMed=7937867;
RA   Nelson K., Selander R.K.;
RT   "Intergeneric transfer and recombination of the 6-phosphogluconate
RT   dehydrogenase gene (gnd) in enteric bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:10227-10231(1994).
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; U14473; AAC43819.1; -; Genomic_DNA.
DR   HSSP; P00349; 2PGD.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:InterPro.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   InterPro; IPR006183; 6-phosphogluconate_DHase.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
FT   CHAIN        <1   >445       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090044.
FT   NON_TER       1      1
FT   NON_TER     445    445
SQ   SEQUENCE   445 AA;  48834 MW;  2FBD0E46CDAB69A8 CRC64;
     AVMGRNLALN IESRGYTVSV FNRSREKTEE VIAENPGKKL VPHYTVKEFV ESLETPRRIL
     LMVKAGAGTD SAIDSLKPYL DKGDIIIDGG NTFFQDTIRR NRELSADGFN FIGTGVSGGE
     EGALKGPSIM PGGQKEAYEL VAPILEQIAA RAEDGEPCVA YIGADGAGHY VKMVHNGIEY
     GDMQLIAEAY ALLKGGLALS NEELATTFTE WNQGELSSYL IDITKDIFTK KDEEGKYLVD
     VILDEAANKG TGKWTSQSSL DLGEPLSLIT ESVFARYISS LKDQRVAASK VLTGPQAQPA
     SDKAEFIEKV RRALYLGKIV SYAQGFSQLR AASNEYSWDL NYGEIAKIFR AGCIIRAQFL
     QKITDAYEEN AGIANLLLAP YFKQIADEYQ QALRDVVAYA VQNGIPVPTF SAAIAYYDSY
     RSAVLPANLI QAQRDYFGAH TYKRT
//