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UniProtKB/Swiss-Prot entry P41680

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_PERMA
Primary accession number P41680
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Alcohol dehydrogenase A subunit
Gene name
Name: ADH1
Synonyms: ADH-1
From
Peromyscus maniculatus (Deer mouse) [TaxID: 10042] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Neotominae; Peromyscus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8227055 [NCBI, ExPASy, EBI, Israel, Japan]
Zheng Y.W., Bey M., Liu H., Felder M.R.;
"Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class.";
J. Biol. Chem. 268:24933-24939(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L15703; AAA40591.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A49107; A49107.
3D structure databases
HSSP P00326; 1HT0. [HSSP ENTRY / PDB]
SMR P41680; 2-375.
ModBase P41680.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet P41680.
Phylogenomic databases
HOVERGEN P41680; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   375  374     Alcohol dehydrogenase 1. PRO_0000160667
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   175   175        Zinc 1; catalytic (By similarity). 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 39834 Da [This is the MW of the unprocessed precursor] CRC64: BA6878B0A071F901 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEPHK PFSIEDIEVA PPKAHEVRIK MVATGVCRSD DHVVSRSLAS 

        70         80         90        100        110        120 
PLPAVLGHEG AGIVESVGEG VTSVKPGDKV IPLFTPQCGK CRICKHPEYN LCMKNDLMQP 

       130        140        150        160        170        180 
RGTLLDGTSR FTCRGKAIHN FISTSTFSQY TVVDEMAVAK IDGASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVAKV TPGSTCAVFG LGGVGLSVII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPLDYSKP IQEVLQEMTD GGVDFSFEVI GRLDTMTSSL LSCHASCGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLSVNPMSLL MGRSWKGAIF GGFKSKDSVP KLVTDFMAKK FPLEPLITHV LPFEKINEAF 

       370 
DLLRAGKSIR TVLTF
P41680 in FASTA format

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