[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0378-1119(89)90152-2; PubMed=2606357 [NCBI, ExPASy, EBI, Israel, Japan] O'Connell M.J., Kelly J.M.; "Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger."; Gene 84:173-180(1989).

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M32351; AAA87596.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P05091; 1O01. [HSSP ENTRY / PDB]

ModBase

P41751.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 497`	`497`	`Aldehyde dehydrogenase.`	`PRO_0000056436`
`NP_BIND`	`242 247`	`6`	`NAD (By similarity).`
`ACT_SITE`	`265 265`		`Proton acceptor (By similarity).`
`ACT_SITE`	`299 299`		`Nucleophile (By similarity).`
`SITE`	`166 166`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 497 AA [This is the length of the unprocessed precursor]

Molecular weight: 53809 Da [This is the MW of the unprocessed precursor]

CRC64: 47CA353FFD8A50E8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA VHEATEKDVD 

        70         80         90        100        110        120 
TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL ASIEALDNGK SITMAHGDIA 

       130        140        150        160        170        180 
GAAGCLRYYG GWADKIHGQT IDTNSETLNY TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI 

       190        200        210        220        230        240 
ATGNTVVIKT AEQTPLSGLY AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF 

       250        260        270        280        290        300 
TGSTLVGRTI LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC 

       310        320        330        340        350        360 
AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI MEYIQHGKDA 

       370        380        390        400        410        420 
GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP VVTVQKFKDV EDAIKIGNST 

       430        440        450        460        470        480 
SYGLAAGIHT KDVTTAIRVS NALRAGTVWV NSYNLIQYQV PFGGFKESGI GRELGSYALE 

       490 
NYTQIKAVHY RLGDALF

P41751 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools