ID   ALDH_ASPNG              Reviewed;         497 AA.
AC   P41751;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2008, entry version 42.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            Short=ALDDH;
DE            Short=ALDH;
DE            EC=1.2.1.3;
GN   Name=aldA;
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90108706; PubMed=2606357; DOI=10.1016/0378-1119(89)90152-2;
RA   O'Connell M.J., Kelly J.M.;
RT   "Physical characterization of the aldehyde-dehydrogenase-encoding gene
RT   of Aspergillus niger.";
RL   Gene 84:173-180(1989).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; M32351; AAA87596.1; -; Genomic_DNA.
DR   HSSP; P05091; 1O01.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    497       Aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056436.
FT   NP_BIND     242    247       NAD (By similarity).
FT   ACT_SITE    265    265       Proton acceptor (By similarity).
FT   ACT_SITE    299    299       Nucleophile (By similarity).
FT   SITE        166    166       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   497 AA;  53809 MW;  47CA353FFD8A50E8 CRC64;
     MSDLFATITT PNGVKYEQPL GLFIDGEFVK GAEGKTFETI NPSNEKPIVA VHEATEKDVD
     TAVAAARKAF EGSWRQVTPS TRGRMLTKLA DLFERDAEIL ASIEALDNGK SITMAHGDIA
     GAAGCLRYYG GWADKIHGQT IDTNSETLNY TRHEPIGVCG QIIPWNFPLL MWAWKIGPAI
     ATGNTVVIKT AEQTPLSGLY AANVIKEAGI PAGVVNVISG FGRVAGSAIS HHMDIDKVAF
     TGSTLVGRTI LQAAAKSNLK KVTLELGGKS PNIVFNDADI DNAISWANFG IFYNHGQCCC
     AGSRILVQEG IYDKFIARLK ERALQNKVGD PFAKDTFQGP QVSQLQFDRI MEYIQHGKDA
     GATVAVGGER HGTEGYFIQP TVFTDVTSDM KINQEEIFGP VVTVQKFKDV EDAIKIGNST
     SYGLAAGIHT KDVTTAIRVS NALRAGTVWV NSYNLIQYQV PFGGFKESGI GRELGSYALE
     NYTQIKAVHY RLGDALF
//