ID   NDUS7_BOVIN             Reviewed;         216 AA.
AC   P42026; Q2TBS6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 58.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 20 kDa subunit;
DE   AltName: Full=Complex I-20kD;
DE            Short=CI-20kD;
DE   AltName: Full=PSST subunit;
DE   Flags: Precursor;
GN   Name=NDUFS7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Heart;
RX   MEDLINE=92249573; PubMed=1577158; DOI=10.1016/0014-5793(92)80248-F;
RA   Arizmendi J.M., Runswick M.J., Skehel J.M., Walker J.E.;
RT   "NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A
RT   fourth nuclear encoded subunit with a homologue encoded in chloroplast
RT   genomes.";
RL   FEBS Lett. 301:237-242(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits This is a
CC       component of the iron-sulfur (IP) fragment of the enzyme.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the complex I 20 kDa subunit family.
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DR   EMBL; X65020; CAA46154.1; -; mRNA.
DR   EMBL; BC109716; AAI09717.1; -; mRNA.
DR   PIR; S22371; S22371.
DR   RefSeq; NP_001033111.1; -.
DR   UniGene; Bt.315; -.
DR   Ensembl; ENSBTAG00000019419; Bos taurus.
DR   GeneID; 338079; -.
DR   KEGG; bta:338079; -.
DR   HOVERGEN; P42026; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to u...; IEA:InterPro.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006138; NADH_DHase_20kDa_su.
DR   InterPro; IPR014406; NiFe_hyd_3_ssu/Q_oxred_NuoB.
DR   InterPro; IPR006137; OxRdtase_q6.
DR   PANTHER; PTHR11995:SF2; NADH_DH_20kDa; 1.
DR   PANTHER; PTHR11995; NiFe_hyd_3_ssu/Q_oxred_NuoB; 1.
DR   Pfam; PF01058; Oxidored_q6; 1.
DR   TIGRFAMs; TIGR01957; nuoB_fam; 1.
DR   PROSITE; PS01150; COMPLEX1_20K; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S; Direct protein sequencing; Electron transport; Iron;
KW   Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase;
KW   Respiratory chain; Transit peptide; Transport; Ubiquinone.
FT   TRANSIT       1     37       Mitochondrion.
FT   CHAIN        38    216       NADH dehydrogenase [ubiquinone] iron-
FT                                sulfur protein 7, mitochondrial.
FT                                /FTId=PRO_0000020026.
FT   METAL        91     91       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL        92     92       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       156    156       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       186    186       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   216 AA;  23771 MW;  514B8A63C59BE641 CRC64;
     MAALAALRLL HPILAVRSGV GAALQVRGVH SSMAADSPSS TQPAVSQARA VVPKPAALPS
     SRGEYVVAKL DDLINWARRS SLWPMTFGLA CCAVEMMHMA APRYDMDRFG VVFRASPRQS
     DVMIVAGTLT NKMAPALRKV YDQMPEPRYV VSMGSCANGG GYYHYSYSVV RGCDRIVPVD
     IYVPGCPPTA EALLYGILQL QKKIKREKRL RIWYRR
//