[1]	PROTEIN SEQUENCE. PubMed=8240242 [NCBI, ExPASy, EBI, Israel, Japan] Rajas F., Rousset B.; "A membrane-bound form of glutamate dehydrogenase possesses an ATP-dependent high-affinity microtubule-binding activity."; Biochem. J. 295:447-455(1993).

Comments

FUNCTION: Present on the membrane of a cell organelle and confers it the capacity to interact with microtubules in a way regulated by ATP. Potential role as membrane anchor.
CATALYTIC ACTIVITY: L-glutamate + H₂O + NAD(P)⁺ = 2-oxoglutarate + NH₃ + NAD(P)H.
SUBUNIT: Homohexamer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Liver, brain and thyroid.
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

S39010; S39010.

3D structure databases

Ontologies

GO:0031966;	Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

PS00074; GLFV_DEHYDROGENASE; PARTIAL.

Phylogenomic databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Membrane; Mitochondrion; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >33`	`>33`	`Glutamate dehydrogenase 1, mitochondrial.`	`PRO_0000182741`
`NON_CONS`	`20 21`
`NON_TER`	`33 33`

Sequence information

Length: 33 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 3624 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 63B6C5C3C479F4DD [This is a checksum on the sequence]

        10         20         30 
SEAAADREDD PNFFKMVEGF GSILEADXDI LIP

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools