ID   DHE3_PIG                Reviewed;          33 AA.
AC   P42174;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2008, entry version 43.
DE   RecName: Full=Glutamate dehydrogenase 1, mitochondrial;
DE            Short=GDH;
DE            EC=1.4.1.3;
DE   AltName: Full=Membrane protein 50;
DE            Short=MP50;
DE   Flags: Fragments;
GN   Name=GLUD1; Synonyms=GLUD;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=94058982; PubMed=8240242;
RA   Rajas F., Rousset B.;
RT   "A membrane-bound form of glutamate dehydrogenase possesses an ATP-
RT   dependent high-affinity microtubule-binding activity.";
RL   Biochem. J. 295:447-455(1993).
CC   -!- FUNCTION: Present on the membrane of a cell organelle and confers
CC       it the capacity to interact with microtubules in a way regulated
CC       by ATP. Potential role as membrane anchor.
CC   -!- CATALYTIC ACTIVITY: L-glutamate + H(2)O + NAD(P)(+) = 2-
CC       oxoglutarate + NH(3) + NAD(P)H.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Liver, brain and thyroid.
CC   -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
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DR   PIR; S39010; S39010.
DR   HOVERGEN; P42174; -.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006095; Glu/Leu/Phe/Val_DHase.
DR   PROSITE; PS00074; GLFV_DEHYDROGENASE; PARTIAL.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Mitochondrion; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    >33       Glutamate dehydrogenase 1, mitochondrial.
FT                                /FTId=PRO_0000182741.
FT   NON_CONS     20     21
FT   NON_TER      33     33
SQ   SEQUENCE   33 AA;  3624 MW;  63B6C5C3C479F4DD CRC64;
     SEAAADREDD PNFFKMVEGF GSILEADXDI LIP
//