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UniProtKB/Swiss-Prot entry P42328

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH3_BACST
Primary accession number P42328
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Alcohol dehydrogenase
Synonyms EC 1.1.1.1
ADH-HT
Gene name None
From
Bacillus stearothermophilus (Geobacillus stearothermophilus) [TaxID: 1422] 
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NCIMB 12403 / LLD-R;
DOI=10.1111/j.1432-1033.1994.tb18873.x; PubMed=8020473 [NCBI, ExPASy, EBI, Israel, Japan]
Cannio R., Rossi M., Bartolucci S.;
"A few amino acid substitutions are responsible for the higher thermostability of a novel NAD(+)-dependent bacillar alcohol dehydrogenase.";
Eur. J. Biochem. 222:345-352(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z27089; CAA81612.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S45605; S45605.
3D structure databases
PDB
1RJW; X-ray; 2.35 A; A/B/C/D=1-339.[ExPASy / RCSB / EBI]
PDBsum 1RJW; -.
ModBase P42328.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet P42328.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   339  339     Alcohol dehydrogenase. PRO_0000160738
METAL   38    38        Zinc 1; catalytic (By similarity). 
METAL   61    61        Zinc 1; catalytic (By similarity). 
METAL   92    92        Zinc 2 (By similarity). 
METAL   95    95        Zinc 2 (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   106   106        Zinc 2 (By similarity). 
METAL   148   148        Zinc 1; catalytic (By similarity). 
STRAND   2     8  7      
STRAND   14    17  4      
STRAND   27    37  11      
HELIX   39    46  8      
STRAND   49    51  3      
STRAND   55    57  3      
STRAND   63    70  8      
STRAND   82    85  4      
STRAND   87    90  4      
HELIX   96    99  4      
HELIX   103   105  3      
TURN   112   114  3      
STRAND   119   127  9      
HELIX   128   130  3      
HELIX   140   143  4      
HELIX   144   146  3      
HELIX   149   160  12      
STRAND   167   171  5      
HELIX   177   186  10      
STRAND   190   194  5      
HELIX   198   206  9      
STRAND   210   213  4      
TURN   215   217  3      
HELIX   220   228  9      
STRAND   229   238  10      
HELIX   241   250  10      
STRAND   251   259  9      
STRAND   264   270  7      
HELIX   271   276  6      
STRAND   280   283  4      
HELIX   289   300  12      
STRAND   308   312  5      
HELIX   313   315  3      
HELIX   316   324  9      
STRAND   329   335  7      
Sequence information
Length: 339 AA [This is the length of the unprocessed precursor] Molecular weight: 36338 Da [This is the MW of the unprocessed precursor] CRC64: AED17E4A34163430 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKAAVVEQFK EPLKIKEVEK PTISYGEVLV RIKACGVCHT DLHAAHGDWP VKPKLPLIPG 

        70         80         90        100        110        120 
HEGVGIVEEV GPGVTHLKVG DRVGIPWLYS ACGHCDYCLS GQETLCEHQK NAGYSVDGGY 

       130        140        150        160        170        180 
AEYCRAAADY VVKIPDNLSF EEAAPIFCAG VTTYKALKVT GAKPGEWVAI YGIGGLGHVA 

       190        200        210        220        230        240 
VQYAKAMGLN VVAVDIGDEK LELAKELGAD LVVNPLKEDA AKFMKEKVGG VHAAVVTAVS 

       250        260        270        280        290        300 
KPAFQSAYNS IRRGGACVLV GLPPEEMPIP IFDTVLNGIK IIGSIVGTRK DLQEALQFAA 

       310        320        330 
EGKVKTIIEV QPLEKINEVF DRMLKGQING RVVLTLEDK
P42328 in FASTA format

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