[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-190.
TISSUE=T-cell;
PubMed=7983002 [NCBI, ExPASy, EBI, Israel, Japan]
Fernandes-Alnemri T.,
Litwack G.,
Alnemri E.S.;
"CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.";
J. Biol. Chem. 269:30761-30764(1994).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0092-8674(95)90541-3; PubMed=7774019 [NCBI, ExPASy, EBI, Israel, Japan]
Tewari M.,
Quan L.T.,
O'Rourke K.,
Desnoyers S.,
Zeng Z.,
Beidler D.R.,
Poirier G.G.,
Salvesen G.S.,
Dixit V.M.;
"Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.";
Cell 81:801-809(1995).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-190.
DOI=10.1016/j.bbrc.2004.02.021; PubMed=15003516 [NCBI, ExPASy, EBI, Israel, Japan]
Pelletier M.,
Cartron P.F.,
Delaval F.,
Meflah K.,
Vallette F.M.,
Oliver L.;
"Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit.";
Biochem. Biophys. Res. Commun. 316:93-99(2004).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Rieder M.J.,
Livingston R.J.,
Daniels M.R.,
Montoya M.A.,
Chung M.-W.,
Miyamoto K.E.,
Nguyen C.P.,
Nguyen D.A.,
Poel C.L.,
Robertson P.D.,
Schackwitz W.S.,
Sherwood J.K.,
Witrak L.A.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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PROTEIN SEQUENCE OF 29-46 AND 175-193, FUNCTION, AND VARIANT ASP-190.
DOI=10.1038/376037a0; PubMed=7596430 [NCBI, ExPASy, EBI, Israel, Japan]
Nicholson D.W.,
Ali A.,
Thornberry N.A.,
Vaillancourt J.P.,
Ding C.K.,
Gallant M.,
Gareau Y.,
Griffin P.R.,
Labelle M.,
Lazebnik Y.A.,
Munday N.A.,
Raju S.M.,
Smulson M.E.,
Yamin T.-T.,
Li V.L.,
Miller D.K.;
"Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.";
Nature 376:37-43(1995).
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[7]
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PROTEOLYTIC PROCESSING.
DOI=10.1073/pnas.93.15.7464; PubMed=8755496 [NCBI, ExPASy, EBI, Israel, Japan]
Fernandes-Alnemri T.,
Armstrong R.C.,
Krebs J.F.,
Srinivasula S.M.,
Wang L.,
Bullrich F.,
Fritz L.C.,
Trapani J.A.,
Tomaselli K.J.,
Litwack G.,
Alnemri E.S.;
"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.";
Proc. Natl. Acad. Sci. U.S.A. 93:7464-7469(1996).
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[8]
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CLEAVAGE OF HUNTINGTIN.
DOI=10.1038/ng0896-442; PubMed=8696339 [NCBI, ExPASy, EBI, Israel, Japan]
Goldberg Y.P.,
Nicholson D.W.,
Rasper D.M.,
Kalchman M.A.,
Koide H.B.,
Graham R.K.,
Bromm M.,
Kazemi-Esfarjani P.,
Thornberry N.A.,
Vaillancourt J.P.,
Hayden M.R.;
"Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.";
Nat. Genet. 13:442-449(1996).
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[9]
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S-NITROSYLATION.
DOI=10.1126/science.284.5414.651; PubMed=10213689 [NCBI, ExPASy, EBI, Israel, Japan]
Mannick J.B.,
Hausladen A.,
Liu L.,
Hess D.T.,
Zeng M.,
Miao Q.X.,
Kane L.S.,
Gow A.J.,
Stamler J.S.;
"Fas-induced caspase denitrosylation.";
Science 284:651-654(1999).
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[10]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 28-277.
DOI=10.1038/nsb0796-619; PubMed=8673606 [NCBI, ExPASy, EBI, Israel, Japan]
Rotonda J.,
Nicholson D.W.,
Fazil K.M.,
Gallant M.,
Gareau Y.,
Labelle M.,
Peterson E.P.,
Rasper D.M.,
Ruel R.,
Vaillancourt J.P.,
Thornberry N.A.,
Becker J.W.;
"The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.";
Nat. Struct. Biol. 3:619-625(1996).
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[11]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 35-173 AND 185-277.
DOI=10.1074/jbc.272.10.6539; PubMed=9045680 [NCBI, ExPASy, EBI, Israel, Japan]
Mittl P.R.E.,
di Marco S.,
Krebs J.F.,
Bai X.,
Karanewsky D.S.,
Priestle J.P.,
Tomaselli K.J.,
Gruetter M.G.;
"Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.";
J. Biol. Chem. 272:6539-6547(1997).
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[12]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
DOI=10.1074/jbc.275.21.16007; PubMed=10821855 [NCBI, ExPASy, EBI, Israel, Japan]
Lee D.,
Long S.A.,
Adams J.L.,
Chan G.,
Vaidya K.S.,
Francis T.A.,
Kikly K.,
Winkler J.D.,
Sung C.-M.,
Debouck C.,
Richardson S.,
Levy M.A.,
DeWolf W.E. Jr.,
Keller P.M.,
Tomaszek T.,
Head M.S.,
Ryan M.D.,
Haltiwanger R.C.,
Liang P.-H., ![]()
Janson C.A.,
McDevitt P.J.,
Johanson K.,
Concha N.O.,
Chan W.,
Abdel-Meguid S.S.,
Badger A.M.,
Lark M.W.,
Nadeau D.P.,
Suva L.J.,
Gowen M.,
Nuttall M.E.;
"Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.";
J. Biol. Chem. 275:16007-16014(2000).
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