[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ICH-1S), AND NUCLEOTIDE SEQUENCE [MRNA] OF 14-452 (ISOFORM ICH-1L).
TISSUE=Fetal brain;
DOI=10.1016/S0092-8674(94)90422-7; PubMed=8087842 [NCBI, ExPASy, EBI, Israel, Japan]
Wang L.,
Miura M.,
Bergeron L.,
Zhu H.,
Yuan J.;
"Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.";
Cell 78:739-750(1994).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-172; ALA-178 AND GLY-441.
Rieder M.J.,
Livingston R.J.,
Daniels M.R.,
Montoya M.A.,
Chung M.-W.,
Miyamoto K.E.,
Nguyen C.P.,
Nguyen D.A.,
Poel C.L.,
Robertson P.D.,
Schackwitz W.S.,
Sherwood J.K.,
Witrak L.A.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ICH-1S).
Halleck A.,
Ebert L.,
Mkoundinya M.,
Schick M.,
Eisenstein S.,
Neubert P.,
Kstrang K.,
Schatten R.,
Shen B.,
Henze S.,
Mar W.,
Korn B.,
Zuo D.,
Hu Y.,
LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Fulton R.S.,
Fulton L.A.,
Graves T.A.,
Pepin K.H.,
Wagner-McPherson C.,
Layman D.,
Maas J.,
Jaeger S.,
Walker R.,
Wylie K.,
Sekhon M.,
Becker M.C.,
O'Laughlin M.D.,
Schaller M.E.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E., ![]()
Cordes M.,
Du H.,
Sun H.,
Edwards J.,
Bradshaw-Cordum H.,
Ali J.,
Andrews S.,
Isak A.,
Vanbrunt A.,
Nguyen C.,
Du F.,
Lamar B.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Bielicki L.,
Scott K.,
Holmes A.,
Harkins R.,
Harris A.,
Strong C.M.,
Hou S.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Leonard S.,
Rohlfing T.,
Rock S.M.,
Tin-Wollam A.-M.,
Abbott A.,
Minx P.,
Maupin R.,
Strowmatt C.,
Latreille P.,
Miller N.,
Johnson D.,
Murray J.,
Woessner J.P.,
Wendl M.C.,
Yang S.-P.,
Schultz B.R.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Nelson J.O.,
Berkowicz N.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Bedell J.A.,
Mardis E.R.,
Clifton S.W.,
Chissoe S.L.,
Marra M.A.,
Raymond C.,
Haugen E.,
Gillett W.,
Zhou Y.,
James R.,
Phelps K.,
Iadanoto S.,
Bubb K.,
Simms E.,
Levy R.,
Clendenning J.,
Kaul R.,
Kent W.J.,
Furey T.S.,
Baertsch R.A.,
Brent M.R.,
Keibler E.,
Flicek P.,
Bork P.,
Suyama M.,
Bailey J.A.,
Portnoy M.E.,
Torrents D.,
Chinwalla A.T.,
Gish W.R.,
Eddy S.R.,
McPherson J.D.,
Olson M.V.,
Eichler E.E.,
Green E.D.,
Waterston R.H.,
Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ICH-1L), AND VARIANT LEU-172.
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-452 (ISOFORM 1), AND VARIANT LEU-172.
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 32-108 (ISOFORMS 1/2).
PubMed=11156409 [NCBI, ExPASy, EBI, Israel, Japan]
Droin N.,
Beauchemin M.,
Solary E.,
Bertrand R.;
"Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.";
Cancer Res. 60:7039-7047(2000).
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-452.
TISSUE=Spleen;
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.,
Ohara O.,
Nagase T.,
Kikuno F.R.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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[9]
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CLEAVAGE SITES.
PubMed=8654923 [NCBI, ExPASy, EBI, Israel, Japan]
Xue D.,
Shaham S.,
Horvitz H.R.;
"The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.";
Genes Dev. 10:1073-1083(1996).
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[10]
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INTERACTION WITH LRDD.
DOI=10.1126/science.1095432; PubMed=15073321 [NCBI, ExPASy, EBI, Israel, Japan]
Tinel A.,
Tschopp J.;
"The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.";
Science 304:843-846(2004).
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[11]
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INTERACTION WITH LRDD.
DOI=10.1038/sj.onc.1209569; PubMed=16652156 [NCBI, ExPASy, EBI, Israel, Japan]
Vakifahmetoglu H.,
Olsson M.,
Orrenius S.,
Zhivotovsky B.;
"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.";
Oncogene 25:5683-5692(2006).
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[12]
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X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 167-452 IN COMPLEX WITH INHIBITOR, SUBUNIT, AND DISULFIDE BOND.
DOI=10.1074/jbc.M304895200; PubMed=12920126 [NCBI, ExPASy, EBI, Israel, Japan]
Schweizer A.,
Briand C.,
Grutter M.G.;
"Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.";
J. Biol. Chem. 278:42441-42447(2003).
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