ID   QOR_LEIAM               Reviewed;         340 AA.
AC   P42865;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 41.
DE   RecName: Full=Probable quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
DE   AltName: Full=P36;
OS   Leishmania amazonensis.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
OX   NCBI_TaxID=5659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95107343; PubMed=7808470; DOI=10.1016/0166-6851(94)90147-3;
RA   Liu X., Chang K.P.;
RT   "Identification by extrachromosomal amplification and overexpression
RT   of a zeta-crystallin/NADPH-oxidoreductase homologue constitutively
RT   expressed in Leishmania spp.";
RL   Mol. Biochem. Parasitol. 66:201-210(1994).
CC   -!- CATALYTIC ACTIVITY: NADPH + 2 quinone = NADP(+) + 2 semiquinone.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
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DR   EMBL; L11705; AAA73554.1; -; Genomic_DNA.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR013154; AlcDHase_GroES-like.
DR   InterPro; IPR002085; AlcDHase_SF_Zn.
DR   InterPro; IPR013149; AlcDHase_Zn-bd.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN         1    340       Probable quinone oxidoreductase.
FT                                /FTId=PRO_0000160911.
SQ   SEQUENCE   340 AA;  36272 MW;  4D9255AB56856625 CRC64;
     MSSPSNFKKL QVVSLSKDFR SSTSVVEAHL PEEVPEGMVR VSVKYAGVNA SDLNFTNGSY
     FKNVQPPFDC GFEAAGTVVQ IGAGVANVKV GDHVVLMQYG CFAEFLDAPA ERCIPVPELK
     PEYSVLPVSA LTAAVALGEV GRVKKGDVAL VTAAAGGTGQ IAVQLLKHVY GCTVIGTCSS
     EEKAEFLKSI GCDHVINYKT ESLDGRLHEL CPKGVDVVYE CVGGHTFNDA VRHVAVHARV
     VIIGSISSYK SGEVVPFSDP SGTSVTMLLL VKSASLNGFF LPQFHDVIPK YMANLLQYLK
     AGQVKLFVDK KVFHGLSSVA DAVDHLYSGA NYGKVLVEIQ
//